CD8 NAIVE T-CELL COUNTS DECREASE PROGRESSIVELY IN HIV-INFECTED ADULTS
CD8 NAIVE T-CELL COUNTS DECREASE PROGRESSIVELY IN HIV-INFECTED ADULTS
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DOI：
10.1172/jci117892
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发表时间：
1995-05-01
影响因子：
15.9
通讯作者：
HERZENBERG, LA
中科院分区：
文献类型：
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作者：
ROEDERER, M;DUBS, JG;HERZENBERG, LA
我们在这里显示，在HIV感染的无症状阶段，CD8初始T细胞被耗尽，尽管CD8 T细胞总数在这一阶段增加，但初始CD8 T细胞逐渐丢失，并与总的CD4T细胞计数平行下降。此外，我们还表明，随着CD4细胞总数的下降，初始的CD4T细胞优先丢失。这些发现，在这里介绍的成人，以及在伴随的儿童研究中，首次证明HIV疾病涉及到CD4T细胞和CD8T细胞的丢失，此外，它们为了解HIV感染者免疫缺陷的机制提供了新的见解。由于所有新的T细胞介导的免疫反应都需要原始T细胞，这里介绍的研究还表明，众所周知，在大多数HIV感染者中，CD8总数的增加主要是由于记忆细胞的扩张，因此，记忆CD8T细胞占患有<患者PBMC中T细胞的80%以上；200CD4/亩L，而在未感染的个体中，它们约占15%，由于幼稚和记忆亚群具有非常不同的功能活动，这种改变的幼稚/记忆T细胞代表对于解释来自体外功能研究的数据具有重要的影响。
We show here that CD8 naive T cells are depleted during the asymptomatic stage of HIV infection, Although overall CD8 T cell numbers are increased during this stage, the naive CD8 T cells are progressively lost and fall in parallel with overall CD4 T cell counts, In addition, we show that naive CD4 T cells are preferentially lost as total CD4 cell counts fall, These findings, presented here for adults, and in the accompanying study for children, represent the first demonstration that HIV disease involves the loss of both CD4 T cells and CD8 T cells, Furthermore, they provide a new insight into the mechanisms underlying the immunodeficiency of HIV-infected individuals, since naive T cells are required for all new T cell-mediated immune responses, Studies presented here also show that the well-known increase in total CD8 counts in most HIV-infected individuals is primarily due to an expansion of memory cells, Thus, memory CD8 T cells comprise over 80% of the T cells in PBMC from individuals with < 200 CD4/mu l, whereas they comprise roughly 15% in uninfected individuals, Since the naive and memory subsets have very different functional activities, this altered naive/memory T cell representation has significant consequences for the interpretation of data from in vitro functional studies.