Overweight, obesity, and the risk of recurrent venous thromboembolism
Overweight, obesity, and the risk of recurrent venous thromboembolism
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DOI：
10.1001/archinte.168.15.1678
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发表时间：
2008-08-11
影响因子：
--
通讯作者：
Kyrle, Paul A.
中科院分区：
文献类型：
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作者：
Eichinger, Sabine;Hron, Gregor;Kyrle, Paul A.
背景：超重是首次静脉血栓栓塞的危险因素。超重对复发性静脉血栓形成的风险的影响是不确定的。方法：我们研究了1107例患者，平均46个月后，第一次无端静脉血栓栓塞和抗凝治疗撤出。排除妊娠患者、需要长期抗血栓治疗的患者、既往或继发性血栓形成、天然凝血抑制剂缺乏、狼疮抗凝剂或癌症患者。我们的研究终点是有症状的复发性静脉血栓栓塞。结果：共有168例患者复发性静脉血栓栓塞。复发患者的平均（SD）体重指数（BMI）（计算为体重（kg）除以身高（m）的平方）显著高于未复发患者：28.5（6.0）vs 26.9（5.0）（P= 0.01）。超重与复发之间呈线性关系; BMI每增加1分，调整后的风险比为1.044（95%置信区间[CI]，1.013-1.076）（P
Background: Excess body weight is a risk factor for a first venous thromboembolism. The impact of excess body weight on risk of recurrent venous thrombosis is uncertain.Methods: We studied 1107 patients for an average of 46 months after a first unprovoked venous thromboembolism and withdrawal of anticoagulant therapy. Excluded were pregnant patients, those requiring long-term antithrombotic treatment, and those who had a previous or secondary thrombosis, natural coagulation inhibitor deficiency, lupus anticoagulant, or cancer. Our study end point was symptomatic recurrent venous thromboembolism.Results: A total of 168 patients had recurrent venous thromboembolism. Mean (SD) body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) was significantly higher among patients with recurrence than among those without recurrence: 28.5 (6.0) vs 26.9 (5.0) (P=.01). The relationship between excess body weight and recurrence was linear; the adjusted hazard ratio for each 1-point increase in BMI was 1.044 (95% confidence interval [CI], 1.013-1.076) (P