Using Gold Nanoparticles To Disrupt the Tumor Microenvironment: An Emerging Therapeutic Strategy.
Using Gold Nanoparticles To Disrupt the Tumor Microenvironment: An Emerging Therapeutic Strategy.
复制标题
DOI：
10.1021/acsnano.6b07673
复制
发表时间：
2016-12-27
期刊：
影响因子：
17.1
通讯作者：
Day ES
中科院分区：
文献类型：
--
作者：
Melamed JR;Riley RS;Valcourt DM;Day ES
金纳米粒子作为抗癌药物和治疗性寡核苷酸的载体最近受到了广泛关注，但很少有研究调查其作为独立治疗剂的潜力。以前的研究质疑其短期和长期的全身毒性，发现虽然金纳米颗粒在肝脏和脾脏内积累并缓慢清除，但它们似乎不会在这些器官中产生毒性作用。有趣的是，金纳米粒子天生就表现出通过干扰肿瘤细胞和基质细胞之间的串扰来特异性调节肿瘤微环境的能力。在ACS Nano的这一期中，Mukherjee及其同事证明了裸金纳米颗粒可以通过调节细胞分泌组来干扰胰腺星状细胞和胰腺癌细胞之间的串扰，以减少促纤维增生组织的生长并抑制肿瘤生长。在这个角度来看，我们强调了在肿瘤微环境中抗癌靶向的机会，并讨论了金纳米粒子作为微环境靶向治疗的潜在介质。
Gold nanoparticles have received much attention recently as carriers for anticancer drugs and therapeutic oligonucleotides, but little research has investigated their potential to act as stand-alone therapeutics. Previous studies interrogating their short- and long-term systemic toxicity have found that although gold nanoparticles accumulate within and clear slowly from the liver and spleen, they do not appear to exert toxic effects in these organs. Interestingly, gold nanoparticles innately exhibit the ability to modulate the tumor microenvironment specifically by interfering with crosstalk between tumor cells and stromal cells. In this issue of ACS Nano, Mukherjee and colleagues demonstrate that bare gold nanoparticles can disturb crosstalk between pancreatic stellate cells and pancreatic cancer cells by modulating the cellular secretome to reduce the growth of desmoplastic tissue and inhibit tumor growth. In this Perspective, we highlight opportunities for anticancer targeting within the tumor microenvironment and discuss gold nanoparticles as potential mediators of microenvironment-targeted therapy.