Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians.
Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians.
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可卡因的非线性等效线图和超加性戒断：涡虫中的大麻素组合。
DOI：
10.1016/j.ejphar.2006.10.051
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发表时间：
2007
影响因子：
5
通讯作者：
Tallarida,RonaldJ
中科院分区：
文献类型：
--
作者：
Raffa,RobertB;Stagliano,GregoryW;Tallarida,RonaldJ
阐明多种药物滥用中使用的药物之间的相互作用尤为重要。然而，精确定量分析所需的实验条件很难建立。由于可卡因和大麻素受体激动剂WIN 55212-2的戒断作用在真涡虫中很容易量化，因此可能证明这种组合的某些比例的协同作用（P<0.01）。这种协同作用，在这里分析了最新的（非线性）等辐射线的方法，现在定量建立的第一次。
Elucidation of interactions between drugs used in polydrug abuse is especially important. However, the necessary experimental conditions for precise quantitative analysis are difficult to establish. Because withdrawal effects of cocaine and the cannabinoid receptor agonist WIN 55212-2 are easily quantified in planarians, demonstration of synergistic effects (P<0.01) of certain ratios of this combination was possible. This synergy, here analyzed with the latest (nonlinear) isobolographic methodology, is now quantitatively established for the first time.