Study on the Specificity of α-Tocopheryl (Vitamin E) Acid Succinate Effects on Melanoma, Glioma and Neuroblastoma Cells in Culture 1 2
Study on the Specificity of α-Tocopheryl (Vitamin E) Acid Succinate Effects on Melanoma, Glioma and Neuroblastoma Cells in Culture 1 2
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α-生育酚（维生素 E）酸琥珀酸酯对培养的黑色素瘤、神经胶质瘤和神经母细胞瘤细胞作用的特异性研究 1 2
DOI：
10.3181/00379727-174-41741
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发表时间：
1983
影响因子：
--
通讯作者：
K. Prasad
中科院分区：
文献类型：
--
作者：
B. Rama;K. Prasad
Abstract d- and dl-α-tocopheryl succinate inhibited growth and caused morphological changes in mouse melanoma (B-16), mouse neuroblastoma (NBP2), and rat glioma (C-6) cells in culture. To study whether the effects of α-tocopheryl (vitamin E) succinate on tumor cells are mediated by antioxidant mechanisms, the effects of lipid-soluble antioxidants, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were compared with those of vitamin E succinate. Results showed that these antioxidants produced alterations on the growth and morphology of neuroblastoma, melanoma, and glioma cells which are similar to those produced by vitamin E succinate; however, the extent of the effect depended upon the type of antioxidant and the form of tumor cells. These data suggest that the effects of vitamin E succinate on tumor cells may be mediated, in part, by antioxidant mechanisms.
