Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential
Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential
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DOI：
10.1016/j.neuroimage.2022.119639
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发表时间：
2022-09
期刊：
影响因子：
5.7
通讯作者：
M. Togo;R. Matsumoto;K. Usami;Katsuya Kobayashi;H. Takeyama;T. Nakae;A. Shimotake;T. Kikuchi;Kazumichi Yoshida;M. Matsuhashi;T. Kunieda;Susumu Miyamoto;R. Takahashi;A. Ikeda
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文献类型：
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作者：
M. Togo;R. Matsumoto;K. Usami;Katsuya Kobayashi;H. Takeyama;T. Nakae;A. Shimotake;T. Kikuchi;Kazumichi Yoshida;M. Matsuhashi;T. Kunieda;Susumu Miyamoto;R. Takahashi;A. Ikeda
内侧顶叶皮层是默认模式网络（DMN）的组成部分，在静息状态下活跃。内侧顶叶皮质包括楔前叶和背后扣带皮质（dPCC）。很少有研究提到内侧顶叶皮层的连接差异，这些差异尚未得到精确阐明。电生理连接对于理解皮层功能或功能差异至关重要。由于鲜为人知的是，从内侧顶叶皮层在人类的电生理连接，我们评估了不同的连接模式，内侧顶叶皮层通过构建一个标准化的连接地图，使用皮质-皮质诱发电位（CCEP）。本研究纳入了9例部分性癫痫或脑肿瘤患者，这些患者接受了覆盖内侧顶叶皮质的长期颅内电极放置。单脉冲电刺激被传递到顶叶内侧皮质（38对电极）。使用基线活动的z分数对反应进行标准化，并在蒙特利尔神经研究所（MNI）空间中构建反应密度图。楔前叶倾向于与顶下小叶（IPL）、枕叶皮质、上级顶小叶（SPL）和背侧运动前区（PMd）（4个最活跃的区域，按降序排列）连接，而dPCC倾向于与中扣带回皮质、SPL、楔前叶和IPL连接。楔前叶和dPCC刺激之间的连接模式显著不同（p<0.05）。对于内侧顶叶皮层的每个部分，部分CCEP反应的分布类似于功能连接数据库。根据dPCC如何连接到内侧额叶区，SPL和IPL，其连接模式不能单独用DMN解释，但建议DMN和额顶认知网络的混合物。这些发现提高了我们对内侧顶叶皮质内的连通性的理解。电生理连接是癫痫患者电活动传播的基础。此外，它还有助于我们更好地了解内侧顶叶皮层产生的癫痫网络。
The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p<0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices.