Osteoporosis: An Age-Related and Gender-Specific Disease - A Mini-Review
Osteoporosis: An Age-Related and Gender-Specific Disease - A Mini-Review
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DOI：
10.1159/000166209
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发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Kerschan-Schindl, Katharina
中科院分区：
文献类型：
--
作者：
Pietschmann, Peter;Rauner, Martina;Kerschan-Schindl, Katharina
骨质疏松症是一种典型的与年龄有关的疾病，已知女性比男性更常见，在过去几年中，男性的骨质疏松症报告越来越多。虽然青春期后所有年龄段的男性骨骼都比女性大，导致更大的抗弯强度，但髋部骨折（骨质疏松症的主要并发症之一）后的死亡率在男性中比女性更常见。性激素缺乏与无限制的破骨细胞活性和骨丢失有关。尽管雌激素缺乏在女性中更为明显，但它似乎是两种性别骨质疏松症发病机制的主要因素。与绝经后妇女的骨质疏松症相反，男性骨质疏松症的治疗几乎没有报道。然而，一些常用于治疗女性骨质疏松症的药物似乎对男性也有效。本研究的目的是审查原发性骨质疏松症的老年人，特别强调与性别有关的方面。版权所有（c）2008 S. Karger AG，巴塞尔
Osteoporosis, a classical age-related disease and known to be more common in women than in men, has been reported increasingly often in men during the past few years. Although men at all ages after puberty have larger bones than women, resulting in greater bending strength, mortality after a hip fracture, one of the major complications of osteoporosis, is more common in men than in women. Sex hormone deficiency is associated with unrestrained osteoclast activity and bone loss. Even though estrogen deficiency is more pronounced in women, it appears to be a major factor in the pathogenesis of osteoporosis in both genders. In contrast to osteoporosis in postmenopausal women, the treatment of osteoporosis in men has been scarcely reported. Nevertheless, some drugs commonly used for the treatment of osteoporosis in women also appear to be effective in men. The aim of this study is to review primary osteoporosis in the elderly with particular emphasis on gender-related aspects. Copyright (c) 2008 S. Karger AG, Basel