Diversity of the cochlear and vestibular pathologies in human temporal bones of newborns infected with cytomegalovirus.
Diversity of the cochlear and vestibular pathologies in human temporal bones of newborns infected with cytomegalovirus.
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发表时间：
2022
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通讯作者：
Cureoglu S
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作者：
Tsuprun V;Schleiss MR;Cureoglu S
先天性巨细胞病毒（cCMV）感染新生儿的颞骨可表现为不同的耳蜗和前庭组织病理学，这些新生儿的感音神经性听力损失（SNHL）和前庭功能障碍的变异性相关。cCMV感染人颞骨的耳蜗和前庭病变的研究此前仅有少数报道。光镜下观察3例cCMV感染婴儿4块颞骨的耳蜗前庭组织病理学变化。病例1患儿的颞骨未见巨细胞细胞。淋巴管周围鼓室可见大面积的细胞和非细胞结构；然而，耳蜗和前庭毛细胞未见明显损失。病例2仅在左侧颞骨前庭迷路暗细胞区可见巨细胞、前庭毛细胞缺失和神经纤维缺失。同一婴儿右侧颞骨未见巨细胞细胞；然而，在Corti器官中有外毛细胞的丢失和血管纹的血管增生。病例3的婴儿颞骨显示在耳蜗和内耳前庭部分有巨细胞增生和毛细胞缺失。新生儿cCMV的颞骨表现出不同的耳蜗前庭组织病理学。这种多样性与在感染新生儿中报道的可变SNHL和前庭功能障碍是一致的。
Human temporal bones of newborns with congenital cytomegalovirus (cCMV) infection can be characterized by diverse cochlear and vestibular histopathologies associated with the variability in sensorineural hearing loss (SNHL) and vestibular dysfunction in these newborns. Only a small number of studies on the cochlear and vestibular pathologies in human temporal bones with cCMV infection have been previously reported. Cochleovestibular histopathologies were evaluated in 4 temporal bones from 3 infants with cCMV infection by light microscopy. In one available temporal bone of the infant in Case 1, no cytomegalic cells were found. Large areas of cellular and non-cellular structures were observed in the scala tympani of the perilymphatic space; however, there was no obvious loss of cochlear or vestibular hair cells. In Case 2, cytomegalic cells, a loss of vestibular hair cells, and a loss of nerve fibers were observed only in the area of dark cells in the vestibular labyrinth of the left temporal bone. No cytomegalic cells were found in the right temporal bone of the same infant; however, there was a loss of outer hair cells in the organ of Corti and hypervascularity in the stria vascularis. The one available temporal bone of the infant in Case 3 showed cytomegalic cells and a loss of hair cells in both cochlear and vestibular parts of the inner ear. Human temporal bones of newborns with cCMV demonstrate diverse cochleovestibular histopathologies. This diversity is consistent with the variable SNHL and vestibular dysfunction reported in infected newborns.