Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies.
Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies.
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非人类灵长类动物的衰老和热量限制：行为和体内脑成像研究。
DOI：
10.1111/j.1749-6632.2001.tb05661.x
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发表时间：
2001
影响因子：
5.2
通讯作者：
Lane,MA
中科院分区：
文献类型：
--
作者：
Ingram,DK;Chefer,S;Matochik,J;Moscrip,TD;Weed,J;Roth,GS;London,ED;Lane,MA
翻译后摘要：在一项长期的纵向研究中，老化的恒河猴，一个主要目标是确定老化和热量限制（CR）的行为和神经参数的影响。通过使用自动化设备，可以在猴子的饲养笼中监测运动活动。迄今为止完成的研究表明，与年龄相关的活动明显下降，这与包括人类在内的许多其他物种的观察结果一致。然而，尚未观察到CR对活性的一致影响。选定的猴子群体也参与了脑成像研究，使用磁共振成像（MRI）和正电子发射断层扫描（PET）。迄今为止完成的MRI研究显示，基底神经节、壳核和尾状核的体积明显随年龄而下降，而脑总体积没有变化。PET分析揭示了相同脑区多巴胺D2受体结合潜力的年龄相关性下降。这些结果与人类的发现一致。虽然需要额外的纵向分析来证实目前的结果，它似乎是自发活动，基底神经节的体积，以及多巴胺D2受体结合潜力提供了可靠的，非侵入性的生物标志物的老化恒河猴。
Abstract:In a long‐term longitudinal study of aging in rhesus monkeys, a primary objective has been to determine the effects of aging and caloric restriction (CR) on behavioral and neural parameters. Through the use of automated devices, locomotor activity can be monitored in the home cages of the monkeys. Studies completed thus far indicate a clear age‐related decline in activity consistent with such observations in many other species, including humans. However, no consistent effects of CR on activity have been observed. Selected groups of monkeys have also been involved in brain imaging studies, using magnetic resonance imaging (MRI) and positron emission tomography (PET). MRI studies completed thus far reveal a clear age‐related decline in the volumes of the basal ganglia, the putamen, and the caudate nucleus, with no change in total brain volume. PET analysis has revealed an age‐related decline in the binding potential of dopamine D2receptors in the same brain regions. These results are consistent with findings in humans. Although additional longitudinal analysis is needed to confirm the present results, it would appear that locomotor activity, volume of the basal ganglia, as well as dopamine D2receptor binding potential provide reliable, noninvasive biomarkers of aging in rhesus monkeys.