A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation.
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation.
复制标题
心肌素家族转录共激活因子在心肌细胞成熟中的共同作用。
DOI：
10.1007/s11427-023-2385-x
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Pu,WilliamT
中科院分区：
文献类型：
--
作者：
Guo,Yuxuan;Cao,Yangpo;Jardin,BlakeD;Mazumdar,Neil;Guo,Congting;Yang,Luzi;Lin,Junsen;Chen,Zhan;Ma,Qing;Zhao,Mingming;Dong,Erdan;Pu,WilliamT
In development, after cells make a commitment to their fates, they undergo a continuous and adaptive maturation process to eventually reach their terminal states. Cell maturity often decays during aging and pathogenesis. The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine. Thus, cell maturation studies have recently become a new frontier in developmental biology (Alvarez-Dominguez and Melton, 2022). In cardiac maturation, cardiomyocytes undergo morphology and gene expression changes. Structurally, cardiomyocyte maturation is characterized by the expansion of myofibrils, the biogenesis of mitochondria, and the formation of transverse tubules (T-tubule), which are invaginations of plasma membranes that facilitate electrophysiology (Guo and Pu, 2020). Cardiomyocytes also exhibit tremendous transcription changes (Li et al., 2022), such as myofibril isoform switching and the upregulation of fatty acid oxidation and oxidative phosphorylation genes. These changes collectively establish the robust cardiac function that can be sustained throughout human life and can properly respond to cardiac pathophysiological signals (Hu et al., 2023). We recently discovered serum response factor (SRF) as a central transcription factor that regulates cardiomyocyte maturation (Guo et al., 2018). The activity of SRF is tightly regulated by its myocardin-family co-factors including MYOCD (myocardin), MRTFA (myocardin-related transcription factor-A) and MRTFB (myocardin-related transcription factor-B)(Pipes et al., 2006). MYOCD and MRTFA/B are thought to participate in distinct signal pathways due to their distinct responses to actin dynamics (Pipes et al., 2006). The RPEL domain of MRTFA/B binds monomeric actin, which masks nuclear localization signals to reduce the nuclear localization of MRTFA/B (Mouilleron et al.,
