MEK1-independent activation of MAPK and MEK1-dependent activation of p70 S6 kinase by stem cell factor (SCF) in ovarian cancer cells.
MEK1-independent activation of MAPK and MEK1-dependent activation of p70 S6 kinase by stem cell factor (SCF) in ovarian cancer cells.
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卵巢癌细胞中干细胞因子（SCF）对 MAPK 的 MEK1 依赖性激活和 p70 S6 激酶的 MEK1 依赖性激活。
DOI：
10.1016/j.bbrc.2009.03.031
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发表时间：
2009
影响因子：
3.1
通讯作者：
Chunhong Ma
中科院分区：
文献类型：
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作者：
Lian Liu;Xin Zhang;Chao Du;Xiaoning Zhang;N. Hou;Di Zhao;Jianzhi Sun;Li Li;Xiuwen Wang;Chunhong Ma
我们在表达Kit的卵巢癌细胞系HEY中发现了一条干细胞因子（SCF）触发的、不依赖MEK 1的、依赖PI3K的MAPK活化途径。当我们用RNA干扰（RNAi）敲低MEK1以研究MEK1对卵巢癌细胞增殖和存活的功能时，我们发现MEK1表达被抑制后，尽管MAPK活化保持完整，但细胞生长仍然受损。这表明在SCF诱导的卵巢癌细胞生长过程中存在MEK 1非依赖性的MAPK激活，并且即使当MEK 1未能如预期那样激活MAPK时，它仍然在维持卵巢癌细胞的恶性特性中起关键作用。
We discovered a stem cell factor (SCF)-triggered, MEK1-independent, and PI3K-dependent MAPK activation pathway in the Kit-expressing ovarian cancer cell line HEY. When we knocked down MEK1 with RNA interference (RNAi) to study the function of MEK1 on the proliferation and survival of ovarian cancer cells, we found that impaired cell growth still occurred after MEK1 expression had been suppressed, although MAPK activation remained intact. This suggests that there is MEK1-independent activation of MAPK in the SCF-induced ovarian cancer cell growth process, and that MEK1 still plays a crucial role in maintaining the malignant properties of ovarian cancer cells even when it fails to activate MAPK as expected.
DOI：
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发表时间：
1995-06
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子：
--
作者：
Susan J. Hines;C. Organ;MJ Kornstein;G. Krystal
通讯作者：
Susan J. Hines;C. Organ;MJ Kornstein;G. Krystal