Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer.
Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer.
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DOI：
10.1177/0022034511401622
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发表时间：
2011-06
影响因子：
7.6
通讯作者：
Menezes R
中科院分区：
文献类型：
--
作者：
Andrade Filho PA;Letra A;Cramer A;Prasad JL;Garlet GP;Vieira AR;Ferris RL;Menezes R
口腔鳞状细胞癌（Oral Squamous Cell Carcinoma， OSCC）占上消化道粘膜恶性肿瘤的90%以上。最近对唇腭裂的研究表明，基因与癌症有关。WNT通路基因与几种类型的癌症以及最近与唇裂/腭裂有关。为了研究与唇腭裂相关的基因是否也与口腔癌相关，我们对188例OSCC患者和225例对照患者进行了AXIN2、AXIN1、GSK3β、WNT3A、WNT5A、WNT8A、WNT11、WNT3和WNT9B标记物的基因分型。采用PLINK 1.06软件进行统计分析，检测病例与对照组各多态性等位基因频率的差异。我们发现GSK3B （P=0.0008）和WNT11 （P=0.03）的snp与OSCC相关。我们还在OSCC病例中发现了GSK3B单倍型的过传递。表达分析显示，与对照组织相比，OSCC中WNT3A、GSK3B和AXIN1表达上调，WNT11表达下调（P<0.001）。进一步的研究应侧重于鉴定这些基因中可能导致人类唇裂和口腔癌的功能变异。
Oral Squamous Cell Carcinoma (OSCC) accounts for more than 90% of the malignant neoplasms that arise in the mucosa of the upper aero digestive tract. Recent studies of cleft lip/palate have shown the association of genes involved in cancer. WNT pathway genes have been associated with several types of cancer and recently with cleft lip/palate. To investigate if genes associated with cleft lip/palate were also associated with oral cancer, we genotyped 188 cases with OSCC and 225 control individuals for markers in AXIN2, AXIN1, GSK3β, WNT3A, WNT5A, WNT8A, WNT11, WNT3 and WNT9B. Statistical analysis was performed using PLINK 1.06 software to test for differences in allele frequencies of each polymorphism between cases and controls. We found association of SNPs in GSK3B (P=0.0008) and WNT11 (P=0.03) with OSCC. We also found overtransmission of GSK3B haplotypes in OSCC cases. Expression analyses showed upregulation of WNT3A, GSK3B and AXIN1 and downregulation of WNT11 in OSCC in comparison to control tissues (P<0.001). Additional studies should focus on the identification of potentially functional variants in these genes as contributors to human clefting and oral cancer.
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影响因子：
7.6
作者：
Liu F;Millar SE
通讯作者：
Millar SE
DOI：
10.1002/bdra.20302
发表时间：
2006-08-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Jiang, Rulang
影响因子：
5.8
作者：
Andrade Filho, Pedro A.;Ito, Daisuke;Ferris, Robert L.
通讯作者：
Ferris, Robert L.