A Wireless Implantable Micropump for Chronic Drug Infusion Against Cancer.
A Wireless Implantable Micropump for Chronic Drug Infusion Against Cancer.
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DOI：
10.1016/j.sna.2016.01.001
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发表时间：
2016-03-01
期刊：
影响因子：
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通讯作者：
Meng E
中科院分区：
文献类型：
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作者：
Cobo A;Sheybani R;Tu H;Meng E
我们提出了一种具有微型外形和完全无线操作的可植入微型泵，可用于在自由移动的小型研究动物（如啮齿动物）中评估和开发癌症治疗的慢性药物管理。低功率电解致动器避免了对重型植入式电池的需要。输液系统的特点是E级感应供电系统，提供按需激活泵以及远程调整输送方案，而无需动物处理。微泵的性能通过一个抗癌应用模型来证明，在该模型中，每天提供30 μL的剂量，持续数周，单个泵内的流量变化小于6%，不同泵之间的流量变化小于8%。研究了不同背压、粘度和温度条件下的泵送；参数的选择是为了模拟体内条件。在模拟体内条件下的台式测试中，微泵在30天内提供了一致而可靠的性能，流量变化小于4%。所展示的原型有可能为动态小动物的研究以及药物发现和开发应用提供远程慢性给药的实用解决方案。
We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling. Micropump performance was demonstrated using a model anti-cancer application in which daily doses of 30 μL were supplied for several weeks with less than 6% variation in flow rate within a single pump and less than 8% variation across different pumps. Pumping under different back pressure, viscosity, and temperature conditions were investigated; parameters were chosen so as to mimic in vivo conditions. In benchtop tests under simulated in vivo conditions, micropumps provided consistent and reliable performance over a period of 30 days with less than 4% flow rate variation. The demonstrated prototype has potential to provide a practical solution for remote chronic administration of drugs to ambulatory small animals for research as well as drug discovery and development applications.