A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
复制标题
COCH 神经元回路通过 MTF1 激活 Cacna1h 编码社交压力诱发的焦虑
DOI：
10.1016/j.celrep.2021.110177
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发表时间：
2021-12-28
期刊：
影响因子：
8.8
通讯作者：
Lu, Youming
中科院分区：
文献类型：
--
作者：
Jing, Wei;Zhang, Tongmei;Lu, Youming
海马体是一个颞叶结构，对认知至关重要，如学习，记忆和注意力，以及情绪反应。海马功能障碍可导致持续性焦虑和/或抑郁。然而，海马体中数百万个神经元是如何在分子和结构上组织起来以实现其不同功能的仍然是未知的。在这里，我们基因靶向表达凝血因子C同源物（COCH）基因的神经元的子集。COCH表达神经元或COCH神经元在腹侧CA 3海马的远侧区域中地形隔离，并表达Mtf 1和Cacna 1h。COCH神经元中Cacnalh转录的MTF 1激活编码COCH神经元爆发动作电位并通过与外侧隔中GABA能抑制性神经元的子集直接突触而引起社会应激诱导的焦虑样行为的能力。总之，这项研究提供了一个分子和电路为基础的框架，了解海马COCH神经元是如何组装参与社会行为。
The hippocampus is a temporal lobe structure critical for cognition, such as learning, memory, and attention, as well as emotional responses. Hippocampal dysfunction can lead to persistent anxiety and/or depression. However, how millions of neurons in the hippocampus are molecularly and structurally organized to engage their divergent functions remains unknown. Here, we genetically target a subset of neurons expressing the coagulation factor c homolog (COCH) gene. COCH-expressing neurons or COCH neurons are topographically segregated in the distal region of the ventral CA3 hippocampus and express Mtf1 and Cacna1h. MTF1 activation of Cacnalh transcription in COCH neurons encodes the ability of COCH neurons to burst action potentials and cause social-stress-induced anxiety-like behaviors by synapsing directly with a subset of GABAergic inhibitory neurons in the lateral septum. Together, this study provides a molecular and circuitry-based framework for understanding how COCH neurons in the hippocampus are assembled to engage social behavior.