High Caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women
High Caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women
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DOI：
10.1002/oby.20460
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发表时间：
2013-12-01
期刊：
影响因子：
6.9
通讯作者：
Froy, Oren
中科院分区：
文献类型：
--
作者：
Jakubowicz, Daniela;Barnea, Maayan;Froy, Oren
目的探讨营养素摄入时间与代谢综合征的关系。我们的目标是比较早餐摄入高热量的减肥饮食和晚餐摄入高热量的等热量饮食。设计和方法超重和肥胖妇女（BMI 32.4 +/- 1.8 kg/m2）代谢综合征患者随机分为两组，（约1400千卡）减肥组，早餐（BF）（700千卡早餐，500千卡午餐，200千卡晚餐）或晚餐（D）组（200千卡早餐，500千卡午餐，700千卡晚餐），持续12周。结果BF组体重减轻、腰围缩小明显。虽然两组的空腹血糖、胰岛素和生长激素释放肽均降低，但BF组的空腹血糖、胰岛素和HOMA-IR降低程度更大。BF组的平均甘油三酯水平降低了33.6%，但D组增加了14.6%。口服葡萄糖耐量试验显示BF组血糖和胰岛素下降幅度更大。为了应对膳食挑战，BF组的每日葡萄糖、胰岛素、生长激素释放肽和平均饥饿评分显著降低，而平均饱腹感评分显著升高。结论高热量早餐和减少晚餐摄入是有益的，可能是一个有用的替代肥胖和代谢综合征的管理。
Objective Few studies examined the association between time-of-day of nutrient intake and the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake during breakfast to an isocaloric diet with high caloric intake at dinner. Design and Methods Overweight and obese women (BMI 32.4 +/- 1.8 kg/m2) with metabolic syndrome were randomized into two isocaloric (approximate to 1400 kcal) weight loss groups, a breakfast (BF) (700 kcal breakfast, 500 kcal lunch, 200 kcal dinner) or a dinner (D) group (200 kcal breakfast, 500 kcal lunch, 700 kcal dinner) for 12 weeks. Results The BF group showed greater weight loss and waist circumference reduction. Although fasting glucose, insulin, and ghrelin were reduced in both groups, fasting glucose, insulin, and HOMA-IR decreased significantly to a greater extent in the BF group. Mean triglyceride levels decreased by 33.6% in the BF group, but increased by 14.6% in the D group. Oral glucose tolerance test led to a greater decrease of glucose and insulin in the BF group. In response to meal challenges, the overall daily glucose, insulin, ghrelin, and mean hunger scores were significantly lower, whereas mean satiety scores were significantly higher in the BF group. Conclusions High-calorie breakfast with reduced intake at dinner is beneficial and might be a useful alternative for the management of obesity and metabolic syndrome.