Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
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DOI：
10.1093/ajcn/85.3.788
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发表时间：
2007-03-01
影响因子：
7.1
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Camargo, Carlos A., Jr.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
背景：维生素D缺乏和哮喘在高纬度地区很常见。虽然维生素D具有重要的免疫学作用，但它与哮喘的关系尚不清楚。目的：我们假设孕妇在怀孕期间摄入较高的维生素D与3岁儿童反复喘息的风险较低有关。设计：参与了马萨诸塞州前瞻性产前队列研究Project Viva的1194对母子。我们通过一份有效的食物频率问卷评估了孕妇在怀孕期间对维生素D的摄入量。结果：孕期平均(+/-SD)总维生素D摄入量为548167IU/d。到3岁时，186名儿童(16%)出现反复喘息。与每日摄入量最低四分位数(中位数：356IU)的母亲相比，那些四分位数最高(724IU)的母亲生下反复喘息的风险较低[优势比(OR)：0.39；95%CI：0.25，0.62；Trend<；0.001的P]。无论维生素D是来自饮食(OR：0.81；95%CI：0.69，0.96)还是补充剂(OR：0.82；95%CI：0.73，0.92)，维生素D摄入量增加100IU与较低的风险(OR：0.81；95%CI：0.74，0.89)有关。调整了12个潜在的混杂因素，包括母亲对其他饮食因素的摄入量，没有改变结果。结论：在美国东北部，母亲在怀孕期间摄入较高的维生素D可能会降低儿童早期喘息复发的风险。
Background: Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown.Objective: We hypothesized that a higher maternal intake of vitamin D during pregnancy is associated with a lower risk of recurrent wheeze in children at 3 y of age.Design: The participants were 1194 mother-child pairs in Project Viva-a prospective prebirth cohort study in Massachusetts. We assessed the maternal intake of vitamin D during pregnancy from a validated food-frequency questionnaire. The primary outcome was recurrent wheeze, ie, a positive asthma predictive index ( >= 2 wheezing attacks among children with a personal diagnosis of eczema or a parental history of asthma).Results: The mean (+/- SD) total vitamin D intake during pregnancy was 548 167 IU/d. By age 3 y, 186 children (16%) had recurrent wheeze. Compared with mothers in the lowest quartile of daily intake (median: 356 IU), those in the highest quartile (724 IU) had a lower risk of having a child with recurrent wheeze [odds ratio (OR): 0.39; 95% CI: 0.25, 0.62; P for trend < 0.001]. A 100-IU increase in vitamin D intake was associated with lower risk (OR: 0.81; 95% CI: 0.74, 0.89), regardless of whether vitamin D was from the diet (OR: 0.81; 95% CI: 0.69, 0.96) or supplements (OR: 0.82; 95% CI: 0.73, 0.92). Adjustment for 12 potential confounders, including maternal intake of other dietary factors, did not change the results.Conclusion: In the northeastern United States, a higher maternal intake of vitamin D during pregnancy may decrease the risk of recurrent wheeze in early childhood.