Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats
Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats
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DOI：
10.1016/s0031-9384(98)00336-9
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发表时间：
1999-06-01
影响因子：
2.9
通讯作者：
York, DA
中科院分区：
文献类型：
--
作者：
Greenberg, D;McCaffery, J;York, DA
在对脂肪诱导的肥胖症易感性不同的两种大鼠品系中，测量了十二指肠输注脂肪对假喂养的影响。在大量营养素选择范例中，Osween-Mendel大鼠在高脂肪饮食下易于发展肥胖，并且优先选择脂肪而不是碳水化合物。相比之下，S 5 B/PL大鼠在食用高脂肪饮食时对肥胖有抵抗力，并且在大量营养素选择范例中优先选择碳水化合物。为了检验小肠中脂肪饱腹效力的差异导致两种菌株之间存在这些差异的假设，我们测量了十二指肠输注英脱利匹特和亚油酸钠对假喂养摄入量的影响。结果与假设一致。十二指肠灌注这些脂肪中的任何一种，S5 B/PL大鼠的摄入量显著低于Osween-Mendel大鼠。两种大鼠品系假喂相似的量时，脑内注入0.15 M NaCl。这些结果表明，肠道饱腹机制的反应差异可能有助于这些大鼠品系对脂肪诱导的肥胖症的易感性差异。(C)1999 Elsevier Science Inc.
The effects of duodenal infusions of fats on sham feeding was measured in two strains of rats that differ in their susceptibility to fat-induced obesity. Osborne-Mendel rats are prone to developing obesity on a high-fat diet and preferentially choose fats over carbohydrates in macronutrient selection paradigms. In contrast, S 5B/PL rats are resistant to developing obesity when eating a high-fat diet, and preferentially choose carbohydrates in macronutrient selection paradigms. To test the hypothesis that differences in the satiating potency of fats in the small intestine contributed to these differences between the two strains, we measured the effects of duodenal infusions of Intralipid and sodium linoleate on sham-feeding intakes. The results were consistent with the hypothesis. Duodenal infusions of either of these fats decreased intake significantly more in S5B/PL rats than in Osborne-Mendel rats. Both rat strains sham fed similar amounts when intestinally infused with 0.15 M NaCl. These results suggest that differences in responses to intestinal satiating mechanisms may contribute to the differences in susceptibility to fat-induced obesity in these rat strains. (C) 1999 Elsevier Science Inc.