Therapeutic targeting of STAT pathways in CNS autoimmune diseases.
Therapeutic targeting of STAT pathways in CNS autoimmune diseases.
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DOI：
10.4161/jkst.24134
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Larkin Iii J
中科院分区：
文献类型：
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作者：
Egwuagu CE;Larkin Iii J
信号转导子和转录激活子 (STAT) 转导调节免疫反应的启动、持续时间和强度的细胞外信号。然而，促炎细胞因子或生长因子对 STAT 的无节制激活会导致致病性自身免疫。在这篇综述中，我们简要讨论了促进 T 细胞发育和扩增的 STAT 途径，这些 T 细胞介导两种中枢神经系统炎症性疾病：多发性硬化症 (MS) 和葡萄膜炎。特别关注多发性硬化症和葡萄膜炎的动物模型，以及基于 Th17 细胞和 STAT 通路治疗靶向的中枢神经系统自身免疫性疾病的新治疗方法。
Signal transducers and activators of transcription (STATs) transduce extracellular signals that regulate the initiation, duration and intensity of immune responses. However, unbridled activation of STATs by pro-inflammatory cytokines or growth factors contributes to pathogenic autoimmunity. In this review, we briefly discuss STAT pathways that promote the development and expansion of T cells that mediate two CNS inflammatory diseases, multiple sclerosis (MS) and uveitis. Particular focus is on animal models of MS and uveitis and new approaches to the treatment of CNS autoimmune diseases based on therapeutic targeting of Th17 cells and STAT pathways.