Serum osteocalcin in 1634 healthy children.
Serum osteocalcin in 1634 healthy children.
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1634 名健康儿童的血清骨钙素。
DOI：
10.1093/clinchem/43.3.543
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发表时间：
1997
影响因子：
9.3
通讯作者：
G. Puca
中科院分区：
文献类型：
--
作者：
M. Cioffi;A. Molinari;P. Gazzerro;B. D. Finizio;M. Fratta;Angela Deufemia;G. Puca
骨钙素或骨GLA蛋白(BGP)是成骨细胞合成的一种依赖维生素K的小分子多肽(5800Da)，含49个氨基酸(1)(2)。骨钙素含有三个γ-羧基谷氨酸残基，提供了骨钙素与细胞外基质中的羟基磷灰石之间的相互作用点。19-20和43-44残基为胰酶水解提供了位点；所产生的多肽可能是该分子的肝、肾和血浆分解的产物。这些片段的生理作用尚不清楚。
骨钙素是生理和病理条件下骨转换的重要标志(3)。生理上，儿童的血清骨钙素升高，特别是在生命的第一年和青春期，此时血清骨钙素的浓度变化与身体发育的速度有关。骨钙素与睾酮、血清胰岛素样生长因子-1的显著相关性与…一致
Osteocalcin or bone Gla protein (BGP) is a vitamin K-dependent, low-molecular-mass (5800 Da), 49 amino acid peptide synthesized by osteoblasts (1)(2). Osteocalcin contains three residues of γ-carboxyglutamate, which provide the point of interaction between the BGP and hydroxyapatite in the extracellular bone matrix. The 19–20 and 43–44 residues provide sites for the tryptic hydrolysis; the resulting peptides may be the products of liver, kidney, and plasmatic breakdown of the molecule. The physiological role of these fragments is unknown.
Osteocalcin is an important marker of bone turnover in physiological and pathological conditions (3). Physiologically, serum osteocalcin was increased in children, particularly during the first year of life and during puberty, when the evolution of the concentration was related to the rapidity of physical growth. The significant correlation between BGP and testosterone and serum insulin-like growth factor 1 is consistent with …
通过测量血清骨 Gla 蛋白评估绝经后骨质疏松症的骨转换。
DOI：
--
发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Delmas,PD;Wahner,HW;Mann,KG;Riggs,BL
通讯作者：
Riggs,BL
DOI：
10.1016/s0021-9258(18)42960-2
发表时间：
1981-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
P. Price;M. Williamson;J. W. Lothringer
通讯作者：
P. Price;M. Williamson;J. W. Lothringer