RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN HEALTHY-PERSONS WITH HYPERINSULINEMIA AND NORMAL GLUCOSE-TOLERANCE
RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN HEALTHY-PERSONS WITH HYPERINSULINEMIA AND NORMAL GLUCOSE-TOLERANCE
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DOI：
10.1056/nejm198903163201105
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发表时间：
1989-03-16
影响因子：
158.5
通讯作者：
REAVEN, G
中科院分区：
文献类型：
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作者：
ZAVARONI, I;BONORA, E;REAVEN, G
我们研究了247名健康、血压正常、糖耐量正常的非肥胖受试者中两组的血清胰岛素水平与血脂水平和血压的关系。一组32名受试者被定义为患有高胰岛素血症（血清胰岛素，高于平均值> 2 SD），然后与32名正常胰岛素血症受试者（血清胰岛素在平均值的1 SD内）进行比较，这些受试者在年龄（平均值，39岁）、性别（22名男性和10名女性）和体重指数（24.7）方面匹配。这两组人在吸烟、饮酒和体育锻炼方面的模式相似。高胰岛素血症组口服葡萄糖后血糖水平显著升高（P < 0.05）。此外，平均值（. ±. SEM）品尝血浆甘油三酯水平在高胰岛素血症的受试者中显著更高（1.73 ± 0.01）。0.2与1.24 .+-相比。0.1血浆高密度脂蛋白胆固醇浓度较低（1.21 ± 0.01mmol/L）。0.06与1.43 .+-相比。0.06 mmol/L）。高胰岛素血症组收缩压（126 vs 119 mm Hg; P < 0.05）和舒张压（85 vs 78 mm Hg; P < 0.01）均显著升高。我们的结论是，与胰岛素水平正常的健康受试者组相比，高胰岛素血症和正常葡萄糖耐量的健康人冠心病的危险因素增加。
We studied the relation of serum insulin levels to plasma lipid levels and blood pressure in two groups drawn from among 247 healthy, normotensive nonobese subjects with normal glucose tolerance. One group of 32 subjects was defined as having hyperinsulinemia (serum insulin, > 2 SD above the mean) and then compared with 32 normoinsulinemic subjects (serum insulin within 1 SD of the mean) matched for age (mean, 39 years), sex (22 men and 10 women), and body-mass index (24.7). The two groups had similar patterns of smoking, drinking, and physical exercise. Plasma glucose levels after an oral glucose challenge were significantly highe r (P < 0.05) in the hyperinsulinemic group. In addition, the mean (.+-. SEM) tasting plasma triglyceride levels in subjects with hyperinsulinemia were significantly higher (1.73 .+-. 0.2 vs 1.24 .+-. 0.1 mmol per liter) and the plasma high-density lipoprotein cholesterol concentrations were lower (1.21 .+-. 0.06 vs. 1.43 .+-. 0.06 mmol pe r liter) than in subjects with normoinsulinemia. Both systolic (126 vs. 119 mm Hg; P < 0.05) and diastolic (85 vs 78 mm Hg; P < 0.01) blood pressures were significnanly elevated in the group with hyperinsulinemia. We conclude that healthy persons with hyperinsulinemia and normal glucose tolerance have an increase in risk factors for coronary artery disease, as compared with a well-matched group of healthy subjects with normal insulin levels.