Effects of tea and tea flavonoids on endothelial function and blood pressure: A brief review
Effects of tea and tea flavonoids on endothelial function and blood pressure: A brief review
复制标题
DOI：
10.1111/j.1440-1681.2006.04450.x
复制
发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Hodgson, J. M.
中科院分区：
文献类型：
--
作者：
Hodgson, J. M.
全世界茶的消费量仅次于水。因此，茶的任何生理效应都可能对人群健康产生重大影响。茶是许多人群总类黄酮摄入量的主要贡献者。茶中的类黄酮已被证明具有一系列有助于改善健康的活性和作用。在多项横断面和前瞻性人群研究中，茶摄入量和茶中黄酮类化合物的摄入量与心血管疾病风险降低相关。已经研究了多种可能的机制。本综述的重点是越来越多的证据表明茶黄酮类化合物可以改善内皮功能和降低血压。使用离体血管的体外研究表明茶黄酮类化合物具有血管扩张活性。人类干预试验的结果表明，增加茶和其他饮食来源中的类黄酮摄入量可以改善内皮功能。新出现的数据还表明，受益程度可能与类黄酮代谢有关。茶类黄酮对血压的影响不太一致。动物研究和群体研究的结果与茶的降血压作用一致。然而，短期干预试验（主要是在血压正常的个体中进行）尚未证明茶能降低血压。总体而言，现有数据表明，茶类黄酮对内皮功能的影响，或许还有血压可能是喝茶降低心血管疾病风险的好处的部分原因。
The consumption of tea worldwide is second only to water. Thus, any physiological effects of tea could have a significant impact on population health.Tea is the major contributor to total flavonoid intake in many populations. Flavonoids in tea have been shown to have a range of activities and effects that could contribute to improved health. Tea intake and the intake of flavonoids found in tea have been associated with reduced risk of cardiovascular disease in several cross-sectional and prospective population studies. A variety of possible mechanisms have been investigated. The focus of the present review is on the mounting evidence that tea flavonoids can improve endothelial function and lower blood pressure.In vitro studies using isolated vessels have shown that tea flavonoids possess vasodilator activity. Results of human intervention trials have shown that increased flavonoid intake from tea, as well as other dietary sources, can improve endothelial function. Emerging data also suggest that the degree of benefit may be related to flavonoid metabolism.The effects of tea flavonoids on blood pressure are less consistent. Results of animal studies and population studies are consistent with a blood pressure-lowering effect of tea. However, short-term intervention trials, mainly in normotensive individuals, have not demonstrated any blood pressure reduction with tea.Overall, the available data suggest that the effects of tea flavonoids on endothelial function and, perhaps, blood pressure may be responsible, at least in part, for any benefits of drinking tea on the risk of cardiovascular disease.