The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-lot and GLUT-1 in non-small cell lung cancer
The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-lot and GLUT-1 in non-small cell lung cancer
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DOI：
10.1016/j.ejca.2007.03.027
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发表时间：
2007-06-01
影响因子：
8.4
通讯作者：
De Ruysscher, Dirk
中科院分区：
文献类型：
--
作者：
van Baardwijk, Angela;Dooms, Christophe;De Ruysscher, Dirk
本研究旨在探讨非小细胞肺癌（NSCLC）中F-18-fluoro-2-deoxy-glucose-positron emission tomography扫描的标准化摄取值（SUV）与缺氧相关标志物（HIF-10和CAIX）、增殖相关标志物（Ki-67）和葡萄糖转运蛋白（GLUT-1和GLUT-3）之间的关系。102例计划完全切除的患者在鲁汶或马斯特里赫特/亚琛接受了PET扫描。最大SUV（SUVmax）与生存率和免疫组化染色模式相关。高SUVmax患者的精算生存率较差，最佳判别值为8.0（鲁汶，p = 0.032）和11.0（马斯特里赫特，p = 0.007）。具有高SUVmax的肿瘤以更高比例的HIF-1 α（63.1%对37.9%，p = 0.024）和GLUT-1（82.9%对62.5%，p = 0.025）表达，而不是具有低SUVmax的肿瘤。在CAIX、Ki-67和GLUT-3的表达中未发现显著差异。本研究支持临床前数据，即缺氧与FDG的高摄取相关。(C)2007爱思唯尔有限公司保留所有权利。
The purpose of this study was to investigate the relation between the standardised uptake value (SUV) on F-18-fluoro-2-deoxy-glucose-positron emission tomography scan and hypoxia related markers (HIF-lo( and CAIX), a proliferation-related marker (Ki-67) and glucose transporters (GLUT-1 and GLUT-3) in non-small cell lung cancer (NSCLC). One hundred and two patients, scheduled for complete resection, received a PET scan in Leuven or Maastricht/Aachen. The maximal SUV (SUVmax) was correlated with survival and immunohistochemical staining patterns. The actuarial survival was worse for patients showing a high SUVmax the best discriminative value being 8.0 (Leuven, p = 0.032) and 11.0 (Maastricht, p = 0.007). T umours with a high SUVmax expressed in a higher proportion HIF-1 alpha (63.1% versus 37.9%, p = 0.024) and GLUT-1 (82.9% versus 62.5%, p = 0.025), than tumours with a low SUVmax No significant difference was found in the expression of CAIX, Ki-67 and GLUT-3. This study supports preclinical data that hypoxia is associated with a higher uptake of FDG. (C) 2007 Elsevier Ltd. All rights reserved.