Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study
Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study
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DOI：
10.1096/fj.201700697rr
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发表时间：
2018-04-01
期刊：
影响因子：
4.8
通讯作者：
Garaulet, Marta
中科院分区：
文献类型：
--
作者：
Carmen Collado, Maria;Engen, Phillip A.;Garaulet, Marta
饮食的组成（我们吃的东西）与微生物群分布广泛相关。然而，食物消费的时间（当我们吃东西时）是否会影响人类的微生物群尚不清楚。在10名健康正常体重的年轻女性中进行了一项随机交叉研究，以测试食物摄入时间对唾液和粪便样本中人体微生物群的影响。更具体地说，为了确定晚吃是否会改变人类唾液微生物群的日常节律，我们询问了24小时内4个特定时间点获得的样本中的唾液微生物群，以更好地了解人类食物时间与代谢变化之间的关系。结果显示唾液多样性和细菌相对丰度存在显著的昼夜节律（即，TM7和梭菌）在早期和晚期进食条件下。更重要的是，进餐时间影响了唾液微生物群多样性的昼夜节律，使其在进食条件之间呈反向节律，并且进食晚增加了推定的促炎分类群的数量，在唾液中显示出昼夜节律。在一项随机交叉研究中，我们首次展示了食物摄入时间对人类唾液微生物群的影响。晚吃主餐颠倒了唾液微生物群多样性的每日节律，这可能对宿主的代谢产生有害影响。
The composition of the diet (what we eat) has been widely related to the microbiota profile. However, whether the timing of food consumption (when we eat) influences microbiota in humans is unknown. A randomized, crossover study was performed in 10 healthy normal-weight young women to test the effect of the timing of food intake on the human microbiota in the saliva and fecal samples. More specifically, to determine whether eating late alters daily rhythms of human salivary microbiota, we interrogated salivary microbiota in samples obtained at 4 specific time points over 24 h, to achieve a better understanding of the relationship between food timing and metabolic alterations in humans. Results revealed significant diurnal rhythms in salivary diversity and bacterial relative abundance (i.e., TM7 and Fusobacteria) across both early and late eating conditions. More importantly, meal timing affected diurnal rhythms in diversity of salivary microbiota toward an inverted rhythm between the eating conditions, and eating late increased the number of putative proinflammatory taxa, showing a diurnal rhythm in the saliva. In a randomized, crossover study, we showed for the first time the impact of the timing of food intake on human salivary microbiota. Eating the main meal late inverts the daily rhythm of salivary microbiota diversity which may have a deleterious effect on the metabolism of the host.