RNAdb -: a comprehensive mammalian noncoding RNA database
RNAdb -: a comprehensive mammalian noncoding RNA database
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DOI：
10.1093/nar/gri089
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发表时间：
2005-01-01
影响因子：
14.9
通讯作者：
Mattick, JS
中科院分区：
文献类型：
--
作者：
Pang, KC;Stephen, S;Mattick, JS
近年来，已发现越来越多不编码蛋白质的转录本，其中许多受到发育调控，并似乎具有调控功能。在此，我们描述了一个综合性哺乳动物非编码RNA数据库（RNAdb）的构建，该数据库包含800多种经过实验研究的独特非编码RNA（ncRNA），包括许多与疾病和/或发育过程相关的非编码RNA。该数据库可在http://research.imb.uq.edu.au/RNAdb访问，并可通过多种标准进行搜索。它包含微小RNA（microRNA）和核仁小RNA（snoRNA），但不包括结构性RNA，如核糖体RNA（rRNA）和转运RNA（tRNA），这些在其他地方有编目。该数据库还包含在高质量小鼠和人类cDNA文库中鉴定出的1100多种假定的反义非编码RNA以及近20000种假定的非编码RNA，并且在不久的将来还会添加更多。这些RNA中有许多是大分子，许多经过剪接，有些存在可变剪接。该数据库将作为RNA组学这一新兴领域以及非编码RNA在哺乳动物基因表达和调控中作用的表征的基础而发挥作用。
In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here, we describe the construction of a comprehensive mammalian noncoding RNA database (RNAdb) which contains over 800 unique experimentally studied noncoding RNAs (ncRNAs), including many associated with diseases and/or developmental processes. The database is available at http://research.imb.uq. edu.au/RNAdb and is searchable by many criteria. It includes microRNAs and snoRNAs, but not infrastructural RNAs, such as rRNAs and tRNAs, which are catalogued elsewhere. The database also includes over 1100 putative antisense ncRNAs and almost 20000 putative ncRNAs identified in high-quality murine and human cDNA libraries, with more to be added in the near future. Many of these RNAs are large, and many are spliced, some alternatively. The database will be useful as a foundation for the emerging field of RNomics and the characterization of the roles of ncRNAs in mammalian gene expression and regulation.