Maternal energy stores and diet composition during pregnancy program adolescent blood pressure
Maternal energy stores and diet composition during pregnancy program adolescent blood pressure
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DOI：
10.1161/hc3401.095037
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发表时间：
2001-08-28
期刊：
影响因子：
37.8
通讯作者：
Borja, J
中科院分区：
文献类型：
--
作者：
Adair, LS;Kuzawa, CW;Borja, J
背景-胎儿营养不良被认为是影响晚年血压(BP)的因素。使用出生体重作为胎儿营养不良指标的人类流行病学研究未能确定孕妇营养的具体方面对规划负责。方法和结果-我们在2026名菲律宾青少年中检查了孕妇怀孕期间的营养和婴儿出生体重与收缩压和舒张压(SBP和DBP)的关系。数据是在宿务(菲律宾)纵向健康和营养调查期间前瞻性收集的。在怀孕大约30周时对妇女进行评估，并对儿童从出生到青春期进行跟踪。使用回归模型来检验母亲的总能量摄入量、蛋白质和脂肪的能量百分比、孕期三头肌皮褶厚度和婴儿出生体重与青春期血压的关系，并控制当前年龄、身高、体重指数和其他潜在的混杂因素。在男孩中，母亲的三头肌皮褶厚度与SBP呈显著负相关，在男孩和女孩中，与DBP呈显著负相关。母亲的营养变量减弱了，但并没有消除男孩出生体重与SBP的反向关系。在男孩中，SBP与母亲从蛋白质中摄取的膳食能量百分比呈显著负相关。在女孩中，SBP和DBP与母亲从脂肪中摄取的卡路里百分比呈负相关。没有证据表明目前的饮食、成熟状态、体力活动或社会经济状况混淆了这些关系。结论--母亲的饮食结构和皮下脂肪形式的能量储存对青春期的后代血压有长期影响。
Background-Fetal undernutrition is hypothesized to program blood pressure (BP) later in life. Human epidemiological studies that use birth weight as a proxy for fetal malnutrition fail to identify specific aspects of maternal nutrition responsible, for programming.Methods, and Results-We examined how maternal nutrition during pregnancy and infant birth weight relate to systolic and diastolic BP (SBP and DBP) in 2026 Filipino adolescents. Data were collected prospectively during the Cebu (Philippines) Longitudinal Health and Nutrition Survey. Women were assessed at approximate to 30 weeks gestation, and children were followed from birth through adolescence. Regression models were used to examine how the mothers' total energy intake, percentage of energy from protein and fat, triceps skinfold thickness during pregnancy, and infant birth weight relate to adolescent BP, controlling for current age, height, and body mass index and other potential confounders. Maternal triceps skinfold thickness was significantly inversely related to SBP among boys and to DBP in boys and girls. Maternal nutrition variables attenuated but did not eliminate an inverse birth weight-SBP relationship in boys. SBP was significantly inversely related to the mothers' percent of dietary energy from protein in boys. Among girls, SBP and DBP were inversely related to the mothers' percentage of calories from fat. There was no evidence of confounding of these relationships by current diet, maturation status, physical activity, or socioeconomic status.Conclusions-Maternal diet composition and energy stores in the form of subcutaneous fat have long-term effects on offspring BP in adolescence.