DOES THE GEOMETRIC DESIGN OF CENTRIOLES IMPLY THEIR FUNCTION
DOES THE GEOMETRIC DESIGN OF CENTRIOLES IMPLY THEIR FUNCTION
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DOI：
10.1002/cm.970010206
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
ALBRECHTBUEHLER, G
中科院分区：
文献类型：
--
作者：
ALBRECHTBUEHLER, G
提出了一种用于在微观尺度上定位信号源方向的微小装置的几种构造原理。与布朗运动所证明的热涨落的扰乱影响相容的最简单和最小的装置是一对彼此成直角定向的圆柱体。九个等间距的叶片沿着每个气缸的外壳以倾斜的方式运行。叶片具有凹形横截面，并且以一定的旋转模式围绕圆柱体的圆周弯曲。考虑到这种假设装置与中心粒的惊人相似性，推测中心粒可能会定位细胞内假设信号的方向（例如小鼠成纤维细胞3 T3细胞）。
Several principles of construction of a microscopically small device for locating the directions of signal sources in microscopic dimensions was suggested. The simplest and smallest device compatible with the scrambling influence of thermal fluctuations as demonstrated by Brownian motion is a pair of cylinders oriented at right angles to each other. Nine equally spaced blades run in a pitched fashion along the mantle of each cylinder. The blades have a concave cross-section and bend around the circumference of the cylinder in a certain rotational pattern. Considering the striking similarity of this hypothetical device with centrioles, it is conjectured that centrioles may locate the direction of hypothetical signals inside cells [such as mouse fibroblast 3T3 cells].