Fibrin directs early retinal damage after experimental subretinal hemorrhage.
Fibrin directs early retinal damage after experimental subretinal hemorrhage.
复制标题
纤维蛋白在实验性视网膜下出血后导致早期视网膜损伤。
DOI：
10.1097/00006982-199212020-00018
复制
发表时间：
1991
影响因子：
--
通讯作者：
Maurice B. Landers
中科院分区：
文献类型：
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作者：
Cynthia A. Toth;Lawrence S. Morse;L. Hjelmeland;Maurice B. Landers
黄斑内的视网膜下血液可在许多黄斑疾病中引起视力丧失。实验性视网膜下出血的临床和组织病理学影响进行了评估，在猫。视网膜下出血产生的一个局灶性神经感觉视网膜脱离与微量吸管技术，然后插入针尖经巩膜，让脉络膜血液填充泡。在术后14天内，对实验性病变进行了临床和光学及电子显微镜检查。最初的观察结果包括血凝块组织和纤维蛋白链的收缩。在9个超过1小时的凝块中，有6个凝块中的纤维蛋白与光感受器内节和外节片的撕裂有关。后来的变性进展到涉及覆盖在凝块中纤维蛋白致密区域上的所有视网膜层。出血到视网膜下泡含有组织纤溶酶原激活剂不形成纤维蛋白链或导致感光细胞撕裂。这些发现强调了如果有组织的视网膜下凝块在形成后不久就可以消除，则改善视网膜存活的潜力。
Subretinal blood within the macula may cause visual loss in a number of macular diseases. The clinical and histopathologic effects of experimental subretinal hemorrhage were evaluated in the cat. Subretinal hemorrhages were produced by creating a focal neurosensory retinal detachment with micropipette techniques, then inserting a needle tip transsclerally to allow choroidal blood to fill the bleb. Experimental lesions were examined clinically and with light and electron microscopy during a 14-day postoperative period. Initial observations included clot organization with retraction of fibrin strands. In six of nine clots more than 1 hour old, fibrin was associated with tearing of sheets of photoreceptor inner and outer segments. Later degeneration progressed to involve all retinal layers overlying the densest areas of fibrin in the clots. Hemorrhages into subretinal blebs containing tissue plasminogen activator did not form fibrin strands or cause photoreceptor tearing. These findings highlight the potential for improved retinal survival if organized subretinal clot can be eliminated soon after formation.