Is SS-A/Ro52 a hydrogen peroxide-sensitive signaling molecule?
Is SS-A/Ro52 a hydrogen peroxide-sensitive signaling molecule?
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DOI：
10.1089/ars.2006.1480
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发表时间：
2006-12
影响因子：
6.6
通讯作者：
Y. Nobuhara;S. Kawano;G. Kageyama;D. Sugiyama;J. Saegusa;S. Kumagai
中科院分区：
文献类型：
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作者：
Y. Nobuhara;S. Kawano;G. Kageyama;D. Sugiyama;J. Saegusa;S. Kumagai
SS-A/Ro52(Ro52)蛋白是干燥综合征和系统性红斑狼疮自身抗体的靶点之一。Ro52在结构上属于环-B-盒/螺旋线圈家族，似乎具有多种功能，但其生理功能在很大程度上仍不清楚。在这里，作者证明了过氧化氢而不是其他氧化应激源诱导了Ro52蛋白从细胞质到细胞核的移位，并且这种现象可以通过抑制MAP激酶，特别是ERK来减弱。这些发现增加了SS-A/Ro52可能作为过氧化氢选择性、氧化应激敏感的信号分子的可能性，该信号分子通过MAP激酶途径被激活。
SS-A/Ro52 (Ro52) protein is one of the targets of autoantibodies in Sjogren's syndrome and systemic lupus erythematosus. Ro52 structurally belongs to the RING-B-box/coiled-coil family, which appears to carry out diverse functions, but the physiological function of Ro52 remains largely unknown. Here, the authors demonstrate that hydrogen peroxide but not other oxidative stressors induced translocation of Ro52 protein from the cytoplasm to the nucleus and this phenomenon was attenuated by inhibition of MAP kinases, ERK in particular. These findings raise the possibility that SS-A/Ro52 may function as a hydrogen peroxide-selective, oxidative stress-sensitive signaling molecule that is activated via the MAP kinase pathway.