Recombination and the properties of Tajima's D in the context of approximate-likelihood calculation
Recombination and the properties of Tajima's D in the context of approximate-likelihood calculation
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DOI：
10.1534/genetics.105.043786
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发表时间：
2005-12-01
期刊：
影响因子：
3.3
通讯作者：
Thornton, K
中科院分区：
文献类型：
--
作者：
Thornton, K
我表明，田岛的D，一个常用的总结单核苷酸多态性数据的网站频谱，是一个有偏见的总结的网站频谱。在中性模型下，这种偏差取决于群体重组率。D在总结数据时的这种偏差使得人口统计学参数的推断对关于重组率的假设敏感。
I show that Tajima's D, a commonly used summary of the site frequency spectrum for single-nucleotide polymorphism data, is a biased summary of the site-frequency spectrum. Under neutral models, this bias depends on the population recombination rate. This bias of D in summarizing the data makes inference of demographic parameters sensitive to assumptions about recombination rates.