Dengue virus-like particles: construction and application

Dengue virus-like particles: construction and application
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登革热病毒样颗粒的构建与应用

DOI:
10.1007/s00253-012-3958-7
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发表时间:
2012-03
期刊:
Appl Microbiol Biotechnol
影响因子:
--
通讯作者:
Rao X
Rao X
中科院分区:
其他
文献类型:
--
作者:
Shang W;Liu J;Hu Z;Yang J;Zhu J;Rao X

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病毒样颗粒(vlp)是缺乏病毒特异性遗传物质的壳状病毒。许多病毒结构蛋白可以组装成vlp,它模仿病毒颗粒的整体结构,可以在宿主中引起强烈的免疫反应。登革热病毒(denv)属黄病毒,通过受感染的蚊子叮咬传播给人类。denv引起几种主要在热带和亚热带地区流行的疾病。然而,仍然缺乏有效的登革热治疗措施和预防战略。本文综述了DENV的合成、成熟、DENV VLP的构建策略和影响因素,以及DENV VLP的应用。
Virus-like particles (VLPs) are shell-like viruses that lack virus-specific genetic materials. Many viral-structured proteins can assemble into VLPs, which mimic the overall structure of virus particles and can elicit strong immune responses in a host. Dengue viruses (DENVs), from the genusFlavivirus, are transmitted to humans through the bites of an infectedAedesmosquito. DENVs cause several diseases that prevailed mainly in tropical and subtropical areas. However, effective treatment measures and preventive strategies for dengue diseases are still lacking. The present minireview summarized the assembly and maturation of DENVs, the strategies and effective factors for dengue VLP construction, and the application of DENV VLPs.
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