Toward Clinical X-ray Phase-Contrast CT Demonstration of Enhanced Soft-Tissue Contrast in Human Specimen
Toward Clinical X-ray Phase-Contrast CT Demonstration of Enhanced Soft-Tissue Contrast in Human Specimen
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DOI：
10.1097/rli.0b013e3181e21866
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发表时间：
2010-07-01
影响因子：
6.7
通讯作者：
David, Christian
中科院分区：
文献类型：
--
作者：
Donath, Tilman;Pfeiffer, Franz;David, Christian
目的：与传统的基于衰减的CT相比，使用相位对比的X射线计算机断层扫描（CT）可以提供具有大大增强的软组织对比度的图像。我们报告的第一次扫描记录与相衬CT系统的基础上的X射线光栅干涉仪和传统的X射线管源的人体标本。的可行性和潜在的应用临床前和临床相衬CTwesked.Materials和方法：一个婴儿的手进行了扫描离体在40 kVp管电压。同时记录的衰减和相位对比CT图像进行了定量比较彼此，通过引入一个特定的亨氏单位的相位对比imaging.Results：我们观察到显着增强的软组织对比度的相位图像相比，衰减数据。特别是，肌腱和韧带出现强烈增加的对比度噪声ratio.Conclusions：我们的研究结果表明，巨大的潜力，相位对比CT的临床研究的人体标本，并可能，人类。由于所应用的技术与传统的X射线管和探测器有效地工作，它适合于临床前和临床相衬CT系统的实现。
Objectives: X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a conventional x-ray tube source. Feasibility and potential applications of preclinical and clinical phase-contrast CT are discussed.Materials and Methods: A hand of an infant was scanned ex vivo at 40 kVp tube voltage. The simultaneously recorded attenuation and phase-contrast CT images were quantitatively compared with each other, by introducing a specific Hounsfield unit for phase-contrast imaging.Results: We observe significantly enhanced soft-tissue contrast in the phase images, when compared with the attenuation data. Particularly, tendons and ligaments appear with strongly increased contrast-to-noise ratio.Conclusions: Our results demonstrate the huge potential of phase-contrast CT for clinical investigations of human specimens and, potentially, of humans. Because the applied technique works efficiently with conventional x-ray tubes and detectors, it is suitable for the realization of preclinical and clinical phase-contrast CT systems.