The red queen coupled with directional selection favours the evolution of sex
The red queen coupled with directional selection favours the evolution of sex
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DOI：
10.1111/j.1420-9101.2012.02468.x
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发表时间：
2012-04-01
影响因子：
2.1
通讯作者：
Otto, S. P.
中科院分区：
文献类型：
--
作者：
Hodgson, E. E.;Otto, S. P.
为什么有性生殖会进化成如此普遍的生殖方式，仍然是进化生物学中的一个主要问题。虽然以前的研究表明，增加的性别和重组可以在宿主寄生虫相互作用的存在下进化（红皇后性别假说），许多这些研究都假设多个基因座介导感染与耐药性。然而，数据表明，主要基因座通常参与抗原呈递和识别。在这里，我们探讨了一个模型，只有一个位点介导宿主寄生虫的相互作用，但第二个位点是定向选择。即使这些基因对健身的影响是独立的，我们表明，增加的性别和重组率有利于修改基因，改变遗传混合的速度。这一结果的出现是因为有限种群中的选择性干扰（HillRobertson效应），这也有利于性别。这些结果表明，红皇后假说可能有助于解释性别的进化，通过贡献一种形式的持续选择，干扰在其他位点的定向选择，从而有利于性别和重组。
Why sexual reproduction has evolved to be such a widespread mode of reproduction remains a major question in evolutionary biology. Although previous studies have shown that increased sex and recombination can evolve in the presence of hostparasite interactions (the Red Queen hypothesis for sex), many of these studies have assumed that multiple loci mediate infection vs. resistance. Data suggest, however, that a major locus is typically involved in antigen presentation and recognition. Here, we explore a model where only one locus mediates hostparasite interactions, but a second locus is subject to directional selection. Even though the effects of these genes on fitness are independent, we show that increased rates of sex and recombination are favoured at a modifier gene that alters the rate of genetic mixing. This result occurs because of selective interference in finite populations (the HillRobertson effect), which also favours sex. These results suggest that the Red Queen hypothesis may help to explain the evolution of sex by contributing a form of persistent selection, which interferes with directional selection at other loci and thereby favours sex and recombination.