Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets
Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets
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DOI：
10.2174/0929867322666150818103836
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发表时间：
2015-01-01
影响因子：
4.1
通讯作者：
dos Santos, Jean Leandro
中科院分区：
文献类型：
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作者：
dos Santos Fernandes, Guilherme Felipe;Jornada, Daniela Hartmann;dos Santos, Jean Leandro
结核病（TB）是由分枝杆菌属细菌引起的传染病，主要由结核分枝杆菌（MTB）引起。世界卫生组织的目标是在未来几年内大幅减少病例数量;然而，多重耐药（MDR）和极端耐药（XDR）形式的细菌数量增加以及缺乏对潜伏性结核病的治疗是需要克服的挑战。在这篇综述中，我们已经确定了近年来文献中描述的最有效的化合物的MIC值
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values