The composition of the lupus band test (LBT) on the sun-protected non-lesional (SPNL) skin in patients with cutaneous lupus erythematosus (CLE)
The composition of the lupus band test (LBT) on the sun-protected non-lesional (SPNL) skin in patients with cutaneous lupus erythematosus (CLE)
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DOI：
10.1191/096120399678840945
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发表时间：
1999-01-01
期刊：
影响因子：
2.6
通讯作者：
Fabbri, P
中科院分区：
文献类型：
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作者：
Cardinali, C;Caproni, M;Fabbri, P
本研究的目的是分析皮肤红斑狼疮（CLE）患者真皮-表皮交界处（DEJ）的不同免疫反应物。采用直接免疫荧光（DIF）技术对65例LE特异性皮肤表现患者和18例其他皮肤病患者的防晒非病变（SPNL）皮肤活检进行了检测。65例CLE患者中有19例受系统性LE （SLE）影响。我们采用常规卡方检验分析CLE-SLE组与cle -非sle组狼疮带状试验（LBT）免疫成分的统计学差异，LE患者LET免疫球蛋白中c -3是最常见的成分，IgM是最常见的成分。其他皮肤病患者的DEJ未见免疫反应物。CLE-SLE组与cle -非sle组在DEJ处不同免疫反应物的检测无统计学差异。在SPNL皮肤上进行LET阳性（即使在DEJ只存在一种免疫反应物）是区分红斑狼疮（LE）患者和非红斑狼疮患者的有用和特异性标准。我们还认为，当至少有两种免疫反应物沉积时，尤其是当沉积物由IgG组成时，在SPNL皮肤上的LET阳性具有预后价值。
The objective of this study was to analyse the different immunoreactants at the dermo-epidermal junction (DEJ) of patients with cutaneous lupus erythematosus (CLE). Sun-protected non lesional (SPNL) skin biopsies from 65 patients with specific cutaneous manifestations of LE and from 18 patients with other dermatologic diseases were tested using the direct immunofluorescence (DIF) technique. Nineteen out of 65 patients with CLE were affected by systemic LE (SLE). We used the conventional chi-squared test to analyse statistical differences between CLE-SLE and CLE-non-SLE groups in the immunological composition of lupus band test (LBT).C-3 was the most common component while IgM were the most frequent immunoglobulins (Igs) of LET in LE patients. No immunoreactants could be demonstrated at the DEJ in patients with other dermatologic diseases. No statistical differences could be found between CLE-SLE and CLE-non-SLE groups as regards the detection of the different immunoreactants at the DEJ. A positive LET (even for the presence of only one immunoreactant at the DEJ) performed on SPNL skin represents a useful and specific criterion to distinguish patients with lupus erythematosus (LE) from those without LE. We also believe in a prognostic value of a positive LET on SPNL skin when the deposition of at least two immunoreactants is demonstrated, and especially if the deposits are composed of IgG.