Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder
Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder
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DOI：
10.1002/ajmg.b.30421
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发表时间：
2007-06-05
影响因子：
2.8
通讯作者：
Faraone, Stephen V.
中科院分区：
文献类型：
--
作者：
Li, Jun;Kang, Chuanyuan;Faraone, Stephen V.
ADHD通常被认为是一种高度遗传性疾病，平均遗传度为0.75。单胺氧化酶（MAO）具有A和B两种类型，长期以来一直被认为是ADHD的候选病理底物，最近，两种MAO酶的基因已被检查为疾病的介质。先前的研究表明，30-50%的ADHD儿童会经历持续到青春期的症状，与症状缓解的儿童相比，他们的社会和神经心理功能会受到更大的损害。基因也可能影响这些特征的障碍，并在这种情况下，MAO基因也可能是候选人缓和ADHD的介绍。本研究探讨了青少年ADHD预后与单胺氧化酶基因多态性之间的关系，包括单胺氧化酶基因第8外显子941 T> G多态性（rs 1799835）和第14外显子1460 C> T多态性（rs 1137070），以及A > G多态性。内含子13（rs 1799836）、3 'UTR（rs 1040399）C > T多态性和2327 T> C多态性。在MAOB基因的外显子15中。MAOA基因多态性与ADHD缓解之间存在显著相关性。由于样本量小，以及ADHD结果在种族或地理群体中存在表型和病因异质性的可能性，这些结果必须在推广到其他人群之前进行复制。(c)2007 Wiley-Liss，Inc.
ADHD is generally deemed to be a highly heritable disorder with mean heritability of 0.75. The enzyme monoamine oxidase (MAO), which has both A and B types, has long been considered a candidate pathological substrate for ADHD, and more recently, the genes for both MAO enzymes have been examined as mediators of the illness. Previous studies indicated that 30-50% of children with ADHD will experience symptoms that persist into adolescence and will have more significant impairment in social and neuropsychological functioning compared to those whose symptoms have remitted. Genes may also influence these characteristics of the disorder, and in this context MAO genes may also be candidates for moderating the presentation of ADHD. The current study examined the association between adolescent outcome of ADHD and MAO gene polymorphisms, including the 941T > G polymorphism in exon 8 (rs1799835) and 1460C > T polymorphism in exon 14 (rs1137070) of the MAOA gene, and the A > G polymorphism. in intron13 (rs1799836), C > T polymorphism in the 3'UTR (rs1040399), and 2327T > C polymorphism. in exon15 of the MAOB gene. Significant associations were observed between the MAOA gene polymorphisms and ADHD remission. Due to the small sample size and the possibility of phenotypic and etiologic heterogeneity of ADHD outcomes across ethnic or geographic groups, these results must be replicated before they can be generalized to other populations. (c) 2007 Wiley-Liss, Inc.