Rural youths' understanding of gene x environmental contributors to heritable health conditions: The case of podoconiosis in Ethiopia
Rural youths' understanding of gene x environmental contributors to heritable health conditions: The case of podoconiosis in Ethiopia
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DOI：
10.1371/journal.pntd.0006763
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发表时间：
2018-09-01
影响因子：
3.8
通讯作者：
Tadele, Getnet
中科院分区：
文献类型：
--
作者：
Engdawork, Kibur;McBride, Colleen M.;Tadele, Getnet
目的 评估让青少年传播环境 (GxE) 对脚足病影响的基因的准确信息的可行性，脚足病是埃塞俄比亚南部流行的一种被忽视的热带淋巴水肿。方法对从埃塞俄比亚南部 2 个地区随机抽取的 377 名青少年进行了横断面调查。衡量指标包括GxE知识（4个正确/错误的陈述）、预防行动知识（认可穿鞋和足部卫生）、因果误解（11项与传染有关的项目）和解释GxE的信心（9个不同意/同意的陈述）。结果超过一半（59%）准确地认可基因和环境对脚足病的共同贡献和预防机制（例如穿防护鞋和保持足部卫生） 卫生）。多变量逻辑回归显示，对 GxE 贡献者有准确了解的年轻人报告称具有：受过一定教育、受过这种情况影响的朋友或亲戚，以及之前与健康推广工作者的互动。令人惊讶的是，更准确的 GxE 知识与认可传染作为因果因素呈正相关。 GxE 和预防行动知识的准确性与青少年解释足病相关信息的信心呈正相关。结论青少年有潜力成为足病 GxE 信息的合格传播者。增强青少年对与受影响个体的社会或亲属关系的信心的干预措施可能是最有希望的。努力挑战年轻人对传染病并存的不准确信念，可以加强 GxE 解释与预防行动的联系。
ObjectivesAssess the feasibility of engaging youth to disseminate accurate information about gene by environmental (GxE) influences on podoconiosis, a neglected tropical lymphedema endemic in southern Ethiopia.MethodsA cross sectional survey was conducted with 377 youth randomly selected from 2 districts of Southern Ethiopia. Measures included GxE knowledge (4 true/false statements), preventive action knowledge (endorse wearing shoes and foot hygiene), causal misconceptions (11 items related to contagion) and confidence to explain GxE (9 disagree/agree statements).ResultsOver half (59%) accurately endorsed joint contributions of gene and environment to podoconiosis and preventive mechanisms (e.g., wearing protective shoes and keeping foot hygiene). Multivariable logistic regression showed that youth with accurate understanding about GxE contributors reported having: some education, friends or kin who were affected by the condition, and prior interactions with health extension workers. Surprisingly, higher accurate GxE knowledge was positively associated with endorsing contagion as a causal factor. Accuracy of GxE and preventive action knowledge were positively associated with youth's confidence to explain podoconiosis-related information.ConclusionsYouth have the potential to be competent disseminators of GxE information about podoconiosis. Interventions to foster confidence among youth in social or kin relationships with affected individuals may be most promising. Efforts to challenge youth's co-existing inaccurate beliefs about contagion could strengthen the link of GxE explanations to preventive actions.