Advective transport of nitric oxide in a mathematical model of the afferent arteriole.
Advective transport of nitric oxide in a mathematical model of the afferent arteriole.
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DOI：
10.1152/ajprenal.00141.2002
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发表时间：
2003-05
期刊：
影响因子：
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通讯作者：
Kayne M. Smith;L. Moore;H. Layton
中科院分区：
文献类型：
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作者：
Kayne M. Smith;L. Moore;H. Layton
内皮源性一氧化氮（NO）被认为是短暂的血液中，因为从血浆中快速清除，主要是通过结合到血红蛋白。去除限制NO平流的程度尚不清楚，特别是对于肾传入小动脉（AA）中的血流，其具有3-30 ms的渡越时间。AA流体动力学和肌源性反应的数学模型，包括NO扩散，平流，降解和血管舒张作用被用来估计NO平流运输。模型模拟表明，平流输送本地产生的NO是足够的生理上显着的NO浓度沿沿着大部分AA。平流运输对血红蛋白清除NO不敏感，因为NO-Hb结合速率相对于AA通过时间较慢。因此，血管壁附近的血浆NO浓度受内皮细胞扩散和上游部位平流的影响。模拟还表明，NO平流可能构成一种机制，以稳定小动脉流量，以响应局部血管收缩伴随着增强NO释放。
Endothelium-derived nitric oxide (NO) is thought to be short-lived in blood because of rapid removal from plasma, mainly by binding to Hb. The extent to which removal limits NO advection is unclear, especially for blood flow in the renal afferent arteriole (AA), which has a transit time of 3-30 ms. A mathematical model of AA fluid dynamics and myogenic response that includes NO diffusion, advection, degradation, and vasorelaxant action was used to estimate NO advective transport. Model simulations indicate that advective transport of locally produced NO is sufficient to yield physiologically significant NO concentrations along much of the AA. Advective transport is insensitive to NO scavenging by Hb because the NO-Hb binding rate is slow relative to AA transit time. Hence, plasma NO concentration near the vessel wall is influenced by both diffusion from endothelial cells and advection from upstream sites. Simulations also suggest that NO advection may constitute a mechanism to stabilize arteriolar flow in response to a localized vasoconstriction accompanied by enhanced NO release.