Neuromodulation of memory in the hippocampus by vasopressin
Neuromodulation of memory in the hippocampus by vasopressin
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DOI：
10.1016/s0014-2999(00)00542-2
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发表时间：
2000-09-29
影响因子：
5
通讯作者：
Soumireu-Mourat, B
中科院分区：
文献类型：
--
作者：
Alescio-Lautier, B;Paban, V;Soumireu-Mourat, B
我们分析了[Arg(8)]加压素在记忆过程中的作用，因为我们已经报道，这是加压素增强记忆作用的主要中央靶点结构之一。这一结构沿其背腹轴在功能上存在分化，加压素能系统的表达取决于是否涉及到海马体的背侧或腹侧部分。为此，根据注射部位的不同，对海马区注射加压素的效果进行了评价。我们用小鼠的Go-No Go视觉辨别任务表明，海马体的两个部分都参与了内源性或外源性加压素的影响，但对腹侧部分的敏感性更高。根据非条件性或条件性小鼠脑室注射加压素后Fos蛋白的表达，我们证实腹侧海马区更多地参与了加压素增强记忆过程的作用。这种多肽的作用似乎是特殊的，因为只有少数表达Fos蛋白的海马细胞(齿状回和CA3海马区的细胞)在条件反射小鼠中表达了Fos蛋白。此外，我们还表明，在腹侧海马区，无论是在学习过程的开始还是中期进行治疗，加压素都会产生不同的行为效应，这表明助记环境是理解加压素对腹侧海马区记忆影响的一个重要因素。(C)2000 Elsevier Science B.V.保留所有权利。
The involvement of [Arg(8)]vasopressin in memory processes was analyzed in the hippocampal structure, since we have reported that this is one of the main central target structures of the vasopressin-enhancing effect on memory. This structure is functionally differentiated along its dorsoventral axis, and the expression of the vasopressinergic system is dependent upon whether the dorsal or ventral part of the hippocampus is involved. For this reason, the effect of vasopressin injected into hippocampus was evaluated on the basis of the site of injection. We have shown, using a Go-No Go visual discrimination task with mice that both parts of the hippocampus are involved in the effect of endogenous or exogenous vasopressin, but with higher sensitivity for the ventral part. Based on the expression of Fos protein following intracerebroventricular injection of vasopressin in unconditioned or conditioned mice, we confirmed the greater involvement of the ventral hippocampus in the enhancing effect of vasopressin on memory processes. The effect of the peptide seems specific, since only a few of the hippocampal cells that expressed Fos protein in the unconditioned mice did so in the conditioned mice (cells in the dentate gyrus and the CA3 hippocampal field). Moreover, we have shown that in the ventral hippocampus, vasopressin generates different behavioral effects whether treatment is performed at the beginning or in the middle of the learning process, suggesting that the mnemonic context is an important factor for understanding the effect of vasopressin on memory in the ventral hippocampus. (C) 2000 Elsevier Science B.V. All rights reserved.