SARS-CoV-2 infection and transmission in primary schools in England in June-December, 2020 (sKIDs): an active, prospective surveillance study.
SARS-CoV-2 infection and transmission in primary schools in England in June-December, 2020 (sKIDs): an active, prospective surveillance study.
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DOI：
10.1016/s2352-4642(21)00061-4
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发表时间：
2021-06
影响因子：
36.4
通讯作者：
Ramsay, Mary E.
中科院分区：
文献类型：
--
作者：
Ladhani, Shamez N.;Baawuah, Frances;Beckmann, Joanne;Okike, Ifeanichukwu O.;Ahmad, Shazaad;Garstang, Joanna;Brent, Andrew J.;Brent, Bernadette;Walker, Jemma;Andrews, Nick;Ireland, Georgina;Aiano, Felicity;Amin-Chowdhury, Zahin;Letley, Louise;Flood, Jessica;Jones, Samuel E., I;Borrow, Ray;Linley, Ezra;Zambon, Maria;Poh, John;Saliba, Vanessa;Amirthalingam, Gayatri;Bernal, Jamie Lopez;Brown, Kevin E.;Ramsay, Mary E.
人们对 SARS-CoV-2 在教育环境中感染和传播的风险知之甚少。英国公共卫生部门在英格兰首次全国封锁后，在小学于 2020 年 6 月 1 日部分重新开放时启动了一项名为“学校儿童 (sKID) 的 COVID-19 监测”的研究，以估计教职员工和学生中有症状和无症状 SARS-CoV-2 感染的发生率、血清阳性率和血清转化率。 sKID 是一项积极的前瞻性监测研究，包括两组：每周拭子组和血液采样组。夏季期中假（2020 年 6 月至 7 月中旬）部分学校重新开放后，拭子组每周接受一次鼻拭子检测，持续至少 4 周。采血组还在夏季半学期开始（2020年6月1日至19日）和结束（2020年7月3日至23日）、2020年9月全面重新开放后和秋季学期结束时（2020年11月23日至12月18日）进行了血清SARS-CoV-2抗体采血，以测量既往感染情况。我们使用逻辑回归测试了 SARS-CoV-2 抗体阳性的预测因子。我们计算了第一轮血清阴性并至少进行两轮测试的参与者的抗体血清转化率。夏季半学期期间，131 所学校的 11 966 名参与者（6727 名学生、4628 名工作人员和 611 名工作人员或学生身份不明的人员）采集了 40 501 份拭子。每周 SARS-CoV-2 感染率为每 100 000 名学生 4·1 例（24 463 例中的 1 例；95% CI 0·1–21·8），每 100 000 名教职员工 12·5 例（16 038 例中的 2 例；1·5–45·0）。在招募时，45 所学校的 816 名学生中的 91 名（11·2%；95% CI 7·9–15·1）和 1381 名教职员工中的 209 名（15·1%；11·9–18·9）SARS-CoV-2 抗体呈阳性，与当地社区血清阳性率相似。血清阳性与封锁期间的出勤率（学生 p=0·13，工作人员 p=0·20）或工作人员与学生的接触无关（p=0·37）。暑期半学期结束时，816名学生中的603人（73·9%）和1381名工作人员中的1015人（73·5%）仍在参与监测，其中5人（4名学生，1名工作人员）进行了血清转化。截至 2020 年 12 月，招募时（2020 年 6 月）血清阴性的 1085 名参与者中，有 55 名（5·1%；95% CI 3·8–6·5）已发生血清转化，其中包括 340 名学生中的 19 名（5·6%；3·4–8·6）和 745 名工作人员中的 36 名（4·8%；3·4–6·6） (p=0·60)。在英格兰，小学于 2020 年 6 月和 9 月部分和全面重新开放后，SARS-CoV-2 感染率较低。英国卫生和社会保障部。
Little is known about the risk of SARS-CoV-2 infection and transmission in educational settings. Public Health England initiated a study, COVID-19 Surveillance in School KIDs (sKIDs), in primary schools when they partially reopened from June 1, 2020, after the first national lockdown in England to estimate the incidence of symptomatic and asymptomatic SARS-CoV-2 infection, seroprevalence, and seroconversion in staff and students. sKIDs, an active, prospective, surveillance study, included two groups: the weekly swabbing group and the blood sampling group. The swabbing group underwent weekly nasal swabs for at least 4 weeks after partial school reopening during the summer half-term (June to mid-July, 2020). The blood sampling group additionally underwent blood sampling for serum SARS-CoV-2 antibodies to measure previous infection at the beginning (June 1–19, 2020) and end (July 3–23, 2020) of the summer half-term, and, after full reopening in September, 2020, and at the end of the autumn term (Nov 23–Dec 18, 2020). We tested for predictors of SARS-CoV-2 antibody positivity using logistic regression. We calculated antibody seroconversion rates for participants who were seronegative in the first round and were tested in at least two rounds. During the summer half-term, 11 966 participants (6727 students, 4628 staff, and 611 with unknown staff or student status) in 131 schools had 40 501 swabs taken. Weekly SARS-CoV-2 infection rates were 4·1 (one of 24 463; 95% CI 0·1–21·8) per 100 000 students and 12·5 (two of 16 038; 1·5–45·0) per 100 000 staff. At recruitment, in 45 schools, 91 (11·2%; 95% CI 7·9–15·1) of 816 students and 209 (15·1%; 11·9–18·9) of 1381 staff members were positive for SARS-CoV-2 antibodies, similar to local community seroprevalence. Seropositivity was not associated with school attendance during lockdown (p=0·13 for students and p=0·20 for staff) or staff contact with students (p=0·37). At the end of the summer half-term, 603 (73·9%) of 816 students and 1015 (73·5%) of 1381 staff members were still participating in the surveillance, and five (four students, one staff member) seroconverted. By December, 2020, 55 (5·1%; 95% CI 3·8–6·5) of 1085 participants who were seronegative at recruitment (in June, 2020) had seroconverted, including 19 (5·6%; 3·4–8·6) of 340 students and 36 (4·8%; 3·4–6·6) of 745 staff members (p=0·60). In England, SARS-CoV-2 infection rates were low in primary schools following their partial and full reopening in June and September, 2020. UK Department of Health and Social Care.