Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers
Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers
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DOI：
10.1016/j.neuroimage.2011.02.030
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Kikuchi, Tatsuya
中科院分区：
文献类型：
--
作者：
Ohya, Tomoyuki;Okamura, Toshimitsu;Kikuchi, Tatsuya
脑酶活性可以用正电子发射断层扫描(PET)结合放射性标记的酶底物来量化。我们研究了脑中示踪代谢物的清除率(k(Et))与靶酶活性估计精度(k(3))之间的关系。初步模拟研究表明，K3估计的精度高度依赖于k(Et)，并由几个动力学参数表征，包括k(Et)和真实示踪剂的外流速率(k(2))(βk(Et)/k(2))。高灵敏度的最佳示踪条件为β
Cerebral enzyme activity can be quantified using positron emission tomography (PET) in conjunction with a radiolabeled enzyme substrate. We investigated the relationship between the elimination rate (k(et)) of tracer metabolites from the brain and the precision of target enzyme activity estimation (k(3)). An initial simulation study indicated that the precision of k3 estimates was highly dependent on k(et), and was characterized by several kinetic parameters including the ratio of k(et) and the efflux rate (k(2)) of authentic tracer (beta k(et)/k(2)). The optimal tracer condition for high sensitivity was found to be beta