Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan
Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan
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DOI：
10.1111/jgh.13030
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发表时间：
2016-01-01
影响因子：
4.1
通讯作者：
Mizokami, Masashi
中科院分区：
文献类型：
--
作者：
Ito, Kiyoaki;Yotsuyanagi, Hiroshi;Mizokami, Masashi
背景和目的：日本性传播急性感染基因型乙型肝炎病毒（HBV）的流行率呈上升趋势。基因型A型HBV与成人急性乙型肝炎（AHB）后HBV进展为慢性感染的风险增加相关。在日本进行了一项全国性的调查，以评估基因型A型AHB和慢性乙型肝炎（CHB）的地理分布、临床和病毒学特征。方法：2005 - 2010年招募570例AHB患者，2010 - 2011年招募3682例CHB患者。分别对552例AHB和3619例CHB患者进行HBV基因型检测。比较不同基因型AHB和CHB患者的临床特征。通过分子进化分析检测HBV基因型A的基因组特征。结果：乙型肝炎病毒基因型为2005 - 2010年AHB的优势基因型。系统发育分析表明，基因A型AHB患者的所有菌株均属于Ae亚型。在CHB患者中，基因A型的发生率为4.1%，且基因A型在青壮年人群中呈扩散趋势。在基因型A型CHB患者中，早期肝脏疾病占主导地位，尽管在一些患者中肝脏疾病进展为肝硬化或肝细胞癌。结论：日本AHB和CHB患者HBV基因型分布差异较大。基因A型感染正在日本CHB患者的年轻成人中蔓延。来自日本AHB患者的序列与来自其他日本AHB患者的序列相同或非常相似。
Background and Aims: The prevalence of sexually transmitted acute infections of the genotype A hepatitis B virus (HBV) has been increasing in Japan. Genotype A HBV is associated with an increased risk of HBV progression to chronic infection after acute hepatitis B (AHB) in adults. A nationwide survey was conducted to evaluate the geographic distribution, clinical, and virologic characteristics of genotype A AHB and chronic hepatitis B (CHB) in Japan.Methods: Five hundred seventy AHB patients were recruited between 2005 and 2010, and 3682 CHB patients were recruited between 2010 and 2011. HBV genotypes were determined for 552 and 3619 AHB and CHB patients, respectively. Clinical characteristics were compared among different genotypes in AHB and CHB patients. Genomic characteristics of HBV genotype A were examined by molecular evolutionary analysis.Results: Hepatitis B virus genotype A was the predominant genotype for AHB between 2005 and 2010. Phylogenetic analysis showed that all strains in the AHB patients with genotype A were classified into subtype Ae. Among CHB patients, the occurrence of genotype A was 4.1%, and genotype A was spreading in young adults. In genotype A CHB patients, early stage liver diseases were predominant, although liver diseases progressed to cirrhosis or hepatocellular carcinoma in some patients.Conclusions: The distribution of HBV genotypes is quite different between AHB and CHB in Japanese patients. Genotype A infection is spreading in young adults of Japanese CHB patients. Sequences derived from Japanese AHB patients were identical to or closely resembled the sequences derived from other Japanese AHB patients.