A voxel-based morphometry study of temporal lobe gray matter reductions in Alzheimer's disease
A voxel-based morphometry study of temporal lobe gray matter reductions in Alzheimer's disease
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DOI：
10.1016/s0197-4580(02)00084-2
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发表时间：
2003-03-01
影响因子：
4.2
通讯作者：
Bottino, CM
中科院分区：
文献类型：
--
作者：
Busatto, GF;Garrido, GEJ;Bottino, CM
几项MRI研究报告了阿尔茨海默病（AD）的颞叶体积减少。测量通常是通过在颞叶的选定内侧和外侧部分上手动绘制感兴趣区域（ROI）来获得的，不同研究中的解剖边界选择不同。我们使用全自动的基于体素的形态测量（VBM）的方法来研究14名AD患者（MMSE 14-25）和14名健康对照者的整个颞叶范围内的灰质异常。AD患者的灰质体积显著减少的病灶在内侧和外侧颞区均被检测到，最显著的是在右侧和左侧后海马旁回和左侧后颞下回/梭状回（P < 0.05，经多重比较校正）。在更灵活的统计学阈值（P < 0.001，多重比较未校正），在右侧杏仁核/内皮层、双侧上级颞回的前后边界和左侧颞中回的前部也检测到明显灰质减少的局限性病灶。这些VBM结果证实了AD患者颞叶萎缩性改变的先前发现，并表明这些异常可能仅限于该叶内的特定部位，而不是广泛分布。(C)2002年爱思唯尔科技有限公司All rights reserved.
Several MRI studies have reported reductions in temporal lobe volumes in Alzheimer's disease (AD). Measures have been usually obtained with regions-of-interest (ROI) drawn manually on selected medial and lateral portions of the temporal lobes, with variable choices of anatomical borders across different studies. We used the fully automated voxel-based morphometry (VBM) approach to investigate gray matter abnormalities over the entire extension of the temporal lobe in 14 AD patients (MMSE 14-25) and 14 healthy controls. Foci of significantly reduced gray matter volume in AD patients were detected in both medial and lateral temporal regions, most significantly in the right and left posterior parahippocampal gyri and the left posterior inferior temporal gyrus/fusiform gyrus (P < 0.05, corrected for multiple comparisons). At a more flexible statistical threshold (P < 0.001, uncorrected for multiple comparisons), circumscribed foci of significant gray matter reduction were also detected in the right amygdala/enthorinal cortex, the anterior and posterior borders of the superior temporal gyrus bilaterally, and the anterior portion of the left middle temporal gyrus. These VBM results confirm previous findings of temporal lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution. (C) 2002 Elsevier Science Inc. All rights reserved.