High Level of Plasma Remnant-like Particle Cholesterol May Predispose to Development of Hypertension in Normotensive Subjects
High Level of Plasma Remnant-like Particle Cholesterol May Predispose to Development of Hypertension in Normotensive Subjects
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DOI：
10.1093/ajh/hpt011
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发表时间：
2013-06-01
影响因子：
3.2
通讯作者：
Imaizumi, Tsutomu
中科院分区：
文献类型：
--
作者：
Kasahara, Akiko;Adachi, Hisashi;Imaizumi, Tsutomu
残体样脂蛋白颗粒胆固醇（RLP-C）是一种高度致动脉粥样硬化因子。RLP-C诱导内皮功能障碍并与高胰岛素血症相关。本研究旨在确定在血压正常的受试者中，高血浆RLP-C水平是否易导致高血压的发生。方法在七国研究的日本队列中，共有1485名年龄在50 ~ 40岁之间的受试者接受了健康检查。我们检查了血压、人体测量参数和血液化学，包括空腹RLP-C水平。免疫分离法测定RLP-C水平。我们从分析中排除了676名患有高血压（BP bb0 = 140/90 mm Hg）或正在服用降压药和/或基线时正在服用降脂药的受试者。十年后，681名受试者被重新检查。结果681例基线时血压正常的受试者中，303例在10年后出现高血压。发生高血压的受试者的RLP-C基线水平显著高于血压正常的受试者（3.7 +/- 1.9 vs 3.3 +/- 1.6 mg/dl） （P < 0.01）。多变量logistic回归分析显示，在调整稳态模型评估指标和其他高血压相关因素后，基线RLP-C是高血压发生的显著因素（优势比= 1.05,95% CI = 1.00-1.10; P = 0.04）。结论：在日本社区居住人群中，血压正常者血浆RLP-C水平高可能易患高血压。
BACKGROUNDRemnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal blood pressure (BP).METHODSA total of 1,485 subjects aged >40 years in a Japanese Cohort of the Seven Countries Study received health examinations. We examined BP, anthropometric parameters, and blood chemistries, including fasting RLP-C levels. RLP-C levels were measured by an immune-separation method. We excluded from the analysis 676 subjects who had hypertension (BP >= 140/90 mm Hg), or were on antihypertensive medication, and/or were on antihyperlipidemic medication at baseline. Ten years later, 681 subjects were re-examined.RESULTSOf 681 normotensive subjects at baseline, 303 subjects had developed hypertension 10 years later. Baseline RLP-C level was significantly higher (P < 0.01) in the subjects who developed hypertension than in those who remained normotensive (3.7 +/- 1.9 vs. 3.3 +/- 1.6 mg/dl). Multivariable logistic regression analysis demonstrated that baseline RLP-C was a significant factor for incident hypertension after adjustments for homeostasis model assessment index and other hypertension-related factors (odds ratio = 1.05, 95% CI = 1.00-1.10; P = 0.04).CONCLUSIONSA high level of plasma RLP-C in normotensive subjects may predispose to the development of hypertension in a population of community-dwelling Japanese.