Hyponatremia in patients with traumatic brain injury: incidence, mechanism, and response to sodium supplementation or retention therapy with hydrocortisone
Hyponatremia in patients with traumatic brain injury: incidence, mechanism, and response to sodium supplementation or retention therapy with hydrocortisone
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DOI：
10.1016/j.surneu.2006.11.052
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Kojima, Jun
中科院分区：
文献类型：
--
作者：
Moro, Nobuhiro;Katayama, Yoichi;Kojima, Jun
背景：低钠血症是中枢神经系统疾病患者常见的电解质异常。几项研究中提出了几种机制，如SIADH、垂体功能减退和CSWS，发生率各不相同。我们试图阐明低钠血症的发病率和机制为每种类型的TBI。我们还评估了钠补充和保留疗法的疗效。对于钠潴留治疗，氢化可的松的管理，预计其盐皮质激素的效果，当低钠血症与过量natriureth.Methods：回顾性分析298例TBI 2003年1月至2004年12月进行。结果：298例患者中，50例（16.8%）在病程中出现低钠血症。低钠血症与住院时间相关（P
Background: Hyponatremia is a frequently observed electrolyte abnormality in patients with central nervous system disease. Several mechanisms, such as SIADH, hypopituitarism, and CSWS, have been proposed with varied incidences among several studies. We attempted to clarify the incidence and mechanism of hyponatremia for each type of TBI. We also assessed the efficacy of sodium supplementation and retention therapy. For sodium retention therapy, hydrocortisone was administered, expecting its mineralocorticoid effect, when the hyponatremia was associated with excess natriuresis.Methods: Retrospective analysis of 298 patients with TBI between January 2003 and December 2004 was performed. The incidence, background, clinical data, and outcome were evaluated.Results: Of the 298 patients, 50 (16.8%) presented hyponatremia during the time course. Hyponatremia was associated with longer hospital stay (P