Ab and T cell epitopes of influenza A virus, knowledge and opportunities
Ab and T cell epitopes of influenza A virus, knowledge and opportunities
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DOI：
10.1073/pnas.0609330104
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发表时间：
2007-01-02
影响因子：
11.1
通讯作者：
Sette, Alessandro
中科院分区：
文献类型：
--
作者：
Bui, Huynh-Hoa;Peters, Bjoern;Sette, Alessandro
最近开发了免疫表位数据库和分析资源（IEDB）（www.immuneepitope.org）以捕获表位相关数据。IEDB还拥有各种生物信息学工具，可用于识别新表位以及分析和可视化现有表位数据。在此，进行了全面的分析，（i）汇编和库存现有知识的甲型流感表位和（ii）确定可能的交叉反应性之间的禽流感病毒H5 N1和人类流感病毒株鉴定的表位。目前，IEDB含有来自58种不同毒株和10种甲型流感蛋白的> 600种不同表位。通过使用IEDB分析资源，进行保守性分析，并鉴定了几个保守的和可能交叉反应的表位。还揭示了当前知识中的重大差距，包括与T细胞表位相比缺乏Ab表位，报告的禽流感毒株/亚型的表位数量有限，以及报告的来自血凝素和核蛋白以外的蛋白质的表位数量有限。该分析为研究人员提供了访问现有流感表位数据的资源。与此同时，分析表明，我们的集体知识的差距，应启发方向，进一步研究对甲型流感病毒的免疫力。
The Immune Epitope Database and Analysis Resources (IEDB) (www.immuneepitope.org) was recently developed to capture epitope related data. IEDB also hosts various bioinformatics tools that can be used to identify novel epitopes as well as to analyze and visualize existing epitope data. Herein, a comprehensive analysis was undertaken (i) to compile and inventory existing knowledge regarding influenza A epitopes and (ii) to determine possible cross-reactivities of identified epitopes among avian H5N1 and human influenza strains. At present, IEDB contains > 600 different epitopes derived from 58 different strains and 10 influenza A proteins. By using the IEDB analysis resources, conservancy analyses were performed, and several conserved and possibly cross-reactive epitopes were identified. Significant gaps in the current knowledge were also revealed, including paucity of Ab epitopes in comparison with T cell epitopes, limited number of epitopes reported for avian influenza strains/subtypes, and limited number of epitopes reported from proteins other than hemagglutinin and nucleoprotein. This analysis provides a resource for researchers to access existing influenza epitope data. At the same time, the analysis illustrates gaps in our collective knowledge that should inspire directions for further study of immunity against the influenza A virus.