Physiology and pathophysiology of iron in hemoglobin-associated diseases.
Physiology and pathophysiology of iron in hemoglobin-associated diseases.
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DOI：
10.1016/j.freeradbiomed.2014.03.039
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发表时间：
2014-07
影响因子：
7.4
通讯作者：
Coates TD
中科院分区：
文献类型：
--
作者：
Coates TD
铁过载和铁毒性，无论是由于吸收增加还是由于重复输血引起的铁负荷，都可能是许多慢性贫血发病率和死亡率的主要原因。在过去的十年里，我们对铁稳态的理解取得了重大进展。与此同时，磁共振成像的进步使临床医生能够无创地监测和量化特定器官中的铁浓度。此外，有效的铁螯合剂，包括可以口服的制剂，现在是可用的。这导致严重慢性铁超负荷患者的死亡率和发病率大幅改善。本文综述了铁稳态的关键点，并试图将临床观察输血铁超载患者的背景下，目前的理解，铁稳态在人类。
Iron overload and iron toxicity, whether because of increased absorption or iron loading from repeated transfusions, can be major causes of morbidity and mortality in a number of chronic anemias. Significant advances have been made in our understanding of iron homeostasis over the past decade. At the same time, advances in magnetic resonance imaging have allowed clinicians to monitor and quantify iron concentrations non-invasively in specific organs. Furthermore, effective iron chelators are now available, including preparations that can be taken orally. This has resulted in substantial improvement in mortality and morbidity for patients with severe chronic iron overload. This paper reviews the key points of iron homeostasis and attempts to place clinical observations in patients with transfusional iron overload in context with the current understanding of iron homeostasis in humans.