Caffeine intake, tolerance, and withdrawal in women: a population-based twin study.
Caffeine intake, tolerance, and withdrawal in women: a population-based twin study.
复制标题
DOI：
10.1176/ajp.156.2.223
复制
发表时间：
1999-02
期刊：
影响因子：
--
通讯作者：
K. Kendler;C. Prescott
中科院分区：
文献类型：
--
作者：
K. Kendler;C. Prescott
咖啡因是迄今为止最常消费的精神活性物质。大多数其他合法和非法精神药物的使用和滥用已显示基本上是遗传的。然而，遗传因素对咖啡因摄入、大量使用、中毒、耐受性和戒断的影响在很大程度上是未知的。方法：通过对1934对来自弗吉尼亚双胞胎登记处的女性对双胞胎的个人访谈，评估了以煮咖啡、速溶咖啡、茶和含咖啡因软饮料形式的咖啡因摄入，以及咖啡因中毒、耐受性和戒断。样本包括486对同卵和335对异卵。双胞胎相似性是通过概率一致性、优势比和四分频相关性来评估的。进行生物特征模型拟合。结果：同卵双胞胎在总咖啡因摄入、大量咖啡因使用、咖啡因中毒、咖啡因耐受性和咖啡因戒断方面的相似性明显大于异卵双胞胎。模型拟合表明，这些措施的双胞胎相似性可以完全归因于遗传因素，估计广泛的遗传率在35%到77%之间。结论咖啡因是一种致瘾性精神活性物质。与先前对其他合法和非法精神活性药物的研究结果相似，咖啡因使用、中毒、耐受性和戒断的个体差异在很大程度上受遗传因素的影响。
OBJECTIVE Caffeine is by far the most commonly consumed psychoactive substance. The use and abuse of most other licit and illicit psychoactive drugs have been shown to be substantially heritable. However, the impact of genetic factors on caffeine consumption, heavy use, intoxication, tolerance, and withdrawal is largely unknown. METHOD Caffeine consumption, in the form of brewed coffee, instant coffee, tea, and caffeinated soft drinks, as well as caffeine intoxication, tolerance, and withdrawal, were assessed by personal interviews of 1,934 individual twins from female-female pairs ascertained from the population-based Virginia Twin Registry. The sample included both members of 486 monozygotic and 335 dizygotic pairs. Twin resemblance was assessed by probandwise concordance, odds ratios, and tetrachoric correlations. Biometrical model fitting was also performed. RESULTS The resemblance in twin pairs for total caffeine consumption, heavy caffeine use, caffeine intoxication, caffeine tolerance, and caffeine withdrawal was substantially greater in monozygotic than in dizygotic twin pairs. Model fitting suggested that twin resemblance for these measures could be ascribed solely to genetic factors, with estimated broad heritabilities of between 35% and 77%. CONCLUSIONS Caffeine is an addictive psychoactive substance. Similar to previous findings with other licit and illicit psychoactive drugs, individual differences in caffeine use, intoxication, tolerance, and withdrawal are substantially influenced by genetic factors.