Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy
Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy
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DOI：
10.3390/nu11092118
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发表时间：
2019-09-01
期刊：
影响因子：
5.9
通讯作者：
Shimojo, Naoki
中科院分区：
文献类型：
--
作者：
Fikri, Bahrul;Tani, Yumi;Shimojo, Naoki
可溶性CD 14（sCD 14）是母乳中的一种免疫调节因子。虽然它可能参与预防特应性症状和对食物和吸入性过敏原的致敏，但关于其保护作用存在相互矛盾的证据。在这项研究中，我们调查了初乳中的sCD 14和1个月BM之间的关系，以及在9个月大时完全或几乎完全母乳喂养至4个月大的婴儿中特应性皮炎（AD）和食物和空气过敏原致敏的发展。从哺乳期母亲中收集BM样本，这些母亲参加了在东京进行的2 × 2析因、随机、非治疗对照试验研究，该研究观察了润肤剂和合生元在儿童出生后第一年预防AD和食物过敏的疗效。共分析了258份初乳样本和269份1个月BM样本。我们发现AD组一个月BM sCD 14水平显著低于非AD组。在总体分析中，1个月BM中的sCD 14水平与过敏原致敏性无关，但在无AD的婴儿中，鸡蛋白色致敏性与1个月BM sCD 14呈负相关。结果表明，sCD 14在BM中可能涉及在婴儿早期的特应性表现。
Soluble CD14 (sCD14) is one of the immunomodulatory factors in breast milk (BM). Although it may be involved in the prevention of atopic symptoms and sensitization to both food and inhalant allergens, conflicting evidence exists concerning its protective effects. In this study, we investigated the relationship between sCD14 in colostrum and 1-month BM, and the development of atopic dermatitis (AD) and sensitization to food and aeroallergens at 9 months of age in infants who were exclusively or almost exclusively breastfed up to 4 months of age. BM samples were collected from lactating mothers who participated in a 2 x 2 factorial, randomized, nontreatment controlled trial study set in Tokyo, which looked at the efficacy of emollients and synbiotics in preventing AD and food allergy in children during the first year of life. A total of 258 colostrum samples and 269 1-month BM samples were analyzed. We found that one-month BM sCD14 levels in the AD group were significantly lower than in the non-AD group. Levels of sCD14 in 1-month BM were not related to allergen sensitization in the overall analysis, but egg white sensitization correlated inversely with 1-month BM sCD14 in infants without AD. The results suggest that sCD14 in BM may be involved in atopic manifestations in early infancy.