Association between baseline IL-6 and 1-year recovery in lumbar radicular pain
Association between baseline IL-6 and 1-year recovery in lumbar radicular pain
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DOI：
10.1002/j.1532-2149.2014.502.x
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发表时间：
2014-11-01
影响因子：
3.6
通讯作者：
Roe, C.
中科院分区：
文献类型：
--
作者：
Schistad, E. I.;Espeland, A.;Roe, C.
背景本研究探讨细胞因子对腰椎神经根性疼痛1年恢复的影响。方法对110例有症状的腰椎间盘突出症患者进行为期1年的随访。使用单变量和多元线性回归评估白细胞介素 (IL)-6、IL-8、椎间盘退变和终板变化（Modic 变化）对 Oswestry 残疾指数（ODI 变化；主要结果）以及腰痛 (LBP) 和腿痛视觉模拟量表 (VAS) 变化（次要结果）的影响。结果不太有利的 ODI 结果与较高的血清 IL-6 水平相关（B=-3.41，95% CI） -5.52 至 -1.30，p=0.002），非手术治疗（B=-7.03，95% CI 1.21 至 12.84，p=0.018），基线背痛强度较高（B=-2.28，95% CI -3.21 至 -1.35，p）
BackgroundIn the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined.MethodsIn total, 110 patients with symptomatic lumbar disc herniation were followed for 1 year. Uni- and multivariate linear regression was used to assess the influence of interleukin (IL)-6, IL-8, disc degeneration and endplate changes (Modic changes) on the changes in the Oswestry Disability Index (ODI change; primary outcome) and visual analogue scale (VAS) for low back pain (LBP) and leg pain (secondary outcomes).ResultsLess favourable ODI outcome correlated with higher serum IL-6 levels (B=-3.41, 95% CI -5.52 to -1.30, p=0.002), non-surgical treatment (B=-7.03, 95% CI 1.21 to 12.84, p=0.018), higher baseline back pain intensity (B=-2.28, 95% CI -3.21 to -1.35, p