Aging-Related Multisystem Dysregulation Over the Adult Life Span and Physical Function in Later Life: The Atherosclerosis Risk in Communities (ARIC) Study.
Aging-Related Multisystem Dysregulation Over the Adult Life Span and Physical Function in Later Life: The Atherosclerosis Risk in Communities (ARIC) Study.
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成人寿命期间与衰老相关的多系统失调和晚年身体功能：社区动脉粥样硬化风险 (ARIC) 研究。
DOI：
10.1093/gerona/glac236
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Heiss,Gerardo
中科院分区：
文献类型：
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作者：
Lu,Yifei;Pike,JamesR;Kucharska-Newton,AnnaM;Palta,Priya;Whitsel,EricA;Bey,GangaS;Zannas,AnthonyS;Windham,BGwen;Walker,KeenanA;Griswold,Michael;Heiss,Gerardo
背景多系统失调（Dm）有望作为衰老的指标并预测死亡率。然而，需要研究Dm，其中不太严重的终点指示可修改的老化阶段。身体功能，反映健康的长寿，而不仅仅是长寿，是更相关的老年科学的目标，但还没有得到很好的investigated.MethodsWe测试的中年DM和它的变化超过20年的身体功能在以后的生活中，在5 583动脉粥样硬化的风险在社区研究队列参与者（基线平均年龄54.7）的关联。Dm量化了17种生理学动机的生物标志物相对于其在年轻健康样本中的基线分布的多变量统计偏差。通过握力和短期身体功能成套测验（SPPB）评估身体功能。使用线性回归和有序logistic回归调整年龄，性别，种族，和education.ResultsEvery单位增量在中年Dm与1.71倍的几率有一个较低的SPPB评分进行量化关联。与中年Dm的第一个四分位数相比，第二个四分位数的SPPB评分较低的优势比分别为1.25、1.56和2.45。对于每个SPPB组件测试和握力，观察到相似的分级关联模式。一个反单调关系也被观察到之间的年增长率的Dm和身体function.ConclusionGreater Dm和进展在中年与较低的身体功能在以后的生活。未来对导致DM进展的因素的研究可能会突出保护身体功能的机会。
BackgroundMultisystem dysregulation (Dm) shows promise as a metric of aging and predicts mortality. However, Dm needs to be studied with less severe endpoints indicating modifiable aging stages. Physical function, reflecting healthy longevity rather than just longevity, is more relevant to the goals of geroscience but has not been well investigated.MethodsWe tested the association of midlife Dm and its change over ~20 years with physical function in later life in 5 583 the Atherosclerosis Risk in Communities Study cohort participants (baseline mean age 54.7). Dm quantifies the multivariate statistical deviation of 17 physiologically motivated biomarkers relative to their distribution in a young healthy sample at baseline. Physical function was assessed from grip strength and the Short Physical Performance Battery (SPPB). Associations were quantified using linear regression and ordinal logistic regression adjusting for age, sex, race, and education.ResultsEach unit increment in midlife Dm was associated with 1.71 times the odds of having a lower SPPB score. Compared to the first quartile of midlife Dm, the odds ratios of having a lower SPPB score were 1.25, 1.56, and 2.45, respectively, for the second–fourth quartiles. Similar graded association patterns were observed for each SPPB component test and grip strength. An inverse monotonic relationship also was observed between the annual growth rate of Dm and physical function.ConclusionGreater Dm and progression in midlife were associated with lower physical function in later life. Future studies on the factors that lead to the progression of Dm may highlight opportunities to preserve physical function.